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Titolo:
EFFECT OF SERTINDOLE ON RAISED MESOLIMBIC DOPAMINERGIC ACTIVITY IN THE RAT
Autore:
DOMENEY AM; ARNT J; COSTALL B; NAYLOR RJ; SANCHEZ C; SMITH AG;
Indirizzi:
H LUNDBECK & CO AS,PHARMACOL RES,OTTILIAVEJ 9 DK-2500 COPENHAGEN DENMARK H LUNDBECK & CO AS,PHARMACOL RES DK-2500 COPENHAGEN DENMARK UNIV BRADFORD,SCH PHARM BRADFORD BD7 1DP W YORKSHIRE ENGLAND
Titolo Testata:
Drug development research
fascicolo: 3, volume: 31, anno: 1994,
pagine: 175 - 185
SICI:
0272-4391(1994)31:3<175:EOSORM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RISPERIDONE; SCHIZOPHRENIA; PROFILE;
Keywords:
SERTINDOLE; NUCLEUS ACCUMBENS; RAT; DOPAMINE INFUSION; NEUROLEPTIC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Domeney et al., "EFFECT OF SERTINDOLE ON RAISED MESOLIMBIC DOPAMINERGIC ACTIVITY IN THE RAT", Drug development research, 31(3), 1994, pp. 175-185

Abstract

The effect of sertindole in models of mesolimbic dopamine excess in the rat was evaluated. Sertindole (0.0057-0.011 mu mol/kg = 2.5-5 mu g/kg, sc) and haloperidol (0.13-0.27 mu mol/kg = 50-100 mu g/kg, ip) inhibited the hyperactivity caused by the acute intra-accumbens injectionof amphetamine (20 mu g). The administration of sertindole (0.0057-2.8 mu mol/kg = 2.5 mu g-1.25 mg/kg, sc daily), haloperidol (0.027-0.40 mu mol/kg = 10-150 mu g/kg, ip bd) or clozapine (15-31 mu mol/kg = 5-10 mg/kg, ip, bd) during a 13-day period of dopamine infusion (25 mu g/24 h) into the nucleus accumbens reduced the dopamine-induced hyperactivity response to control levels, except at the highest dose which reduced activity to below control levels. Locomotor activity remained at control levels after discontinuing the dopamine/sertindole treatment regimen, whereas discontinuation of the dopamine/haloperidol treatment regimen resulted in rebound hyperactivity. Sertindole (0.0057 mu mol/kg = 2.5 mu g/kg, sc) given either once daily or once every 2 days prevented the development of hyperactivity in the intra-accumbens dopamineinfusion model. One injection given every 4 days failed to modify theresponse to a dopamine infusion. Sertindole (0.0057 mu mol/kg = 2.5 mu g/kg, sc daily) inhibited hyperactivity caused by unilateral infusion of dopamine (50 mu g/24 h, 13 days) into the left amygdala of rats having right hemispheric dominance (as measured in a turn preference test). In contrast to haloperidol, sertindole failed to initiate circling behaviour following unilateral, intrastriatal injection. In conclusion, sertindole, like haloperidol and clozapine, can reduce raised mesolimbic dopaminergic activity in the rat. Sertindole differs from haloperidol by its ability to return the hyperactivity response to control levels. (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:59:34