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Titolo:
CORRELATION BETWEEN PULMONARY CYTOCHROME-P450 TRANSCRIPTS AND THE ORGAN-SELECTIVE PNEUMOTOXICITY OF 3-METHYLINDOLE
Autore:
RAMAKANTH S; THORNTONMANNING JR; WANG HF; MAXWELL H; YOST GS;
Indirizzi:
UNIV UTAH,DEPT PHARMACOL & TOXICOL,112 SKAGGS HALL SALT LAKE CITY UT 84112 UNIV UTAH,DEPT PHARMACOL & TOXICOL,112 SKAGGS HALL SALT LAKE CITY UT 84112
Titolo Testata:
Toxicology letters
fascicolo: 1, volume: 71, anno: 1994,
pagine: 77 - 85
SICI:
0378-4274(1994)71:1<77:CBPCTA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CDNA-DIRECTED EXPRESSION; SPECIES-DEPENDENT EXPRESSION; METABOLIC-ACTIVATION; GENE SUBFAMILY; HUMAN-LIVER; IDENTIFICATION; LUNG; SEQUENCE; CLONING; HYDROXYLASE;
Keywords:
CYTOCHROME-P450 TRANSCRIPTS; 3-METHYLINDOLE; PULMONARY; HEPATIC; SELECTIVE TOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
S. Ramakanth et al., "CORRELATION BETWEEN PULMONARY CYTOCHROME-P450 TRANSCRIPTS AND THE ORGAN-SELECTIVE PNEUMOTOXICITY OF 3-METHYLINDOLE", Toxicology letters, 71(1), 1994, pp. 77-85

Abstract

3-Methylindole (3MI) is a species- and organ-selective pneumotoxin; goats are the most susceptible species, mice are intermediate in susceptibility, and rabbits are the least susceptible species to its toxicity. Four different cDNA probes representative of human cytochrome P450 genes CYP2F1, CYP4B1, CYP2A6, and CYP2B6 were hybridized against RNA from lung and liver tissues of goat, mouse and rabbit. Transcripts representative of pulmonary P450s CYP2F1, CYP4B] and CYP2B6 were present in goat lung. Transcripts for the CYP2F1 and CYP4B1 genes were observedin rabbit and mouse lung. In general, the probes selectively hybridized to pulmonary but not hepatic transcripts of all three species. The differences in susceptibilities among the three species could not be explained by the lack of 4B1 and 2F1 transcripts in the lungs of mice or rabbits that are less susceptible than goats, but the selective expression in the lung tissues of all three species may participate in theorgan-selective bio-activation and pulmonary toxicity of 3MI in thesespecies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:18:41