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Titolo:
DOWN-REGULATION OF MHC CLASS-I ANTIGEN IN INSULINOMA CELLS CONTROLLEDBY THE R1 ELEMENT OF THE H-2 ENHANCER
Autore:
YE XH; KRALLI A; GE R; RICCIARDI RP; KNOWLES BB;
Indirizzi:
WISTAR INST ANAT & BIOL,36TH & SPRUCE ST PHILADELPHIA PA 19104 WISTAR INST ANAT & BIOL,36TH & SPRUCE ST PHILADELPHIA PA 19104 UNIV CALIF SAN FRANCISCO,SCH MED,DEPT BIOCHEM & BIOPHYS SAN FRANCISCOCA 94143 AMER CYANAMIDE PEARL RIVER NY 10965 UNIV PENN,SCH DENT MED,DEPT MICROBIOL PHILADELPHIA PA 19104
Titolo Testata:
Oncogene
fascicolo: 4, volume: 9, anno: 1994,
pagine: 1195 - 1204
SICI:
0950-9232(1994)9:4<1195:DOMCAI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSFORMED RAT-CELLS; PANCREATIC BETA-CELLS; GENE-EXPRESSION; NEGATIVE REGULATION; TRANSGENIC MICE; FACTOR BINDING; T-ANTIGEN; N-MYC; MOUSE; COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
X.H. Ye et al., "DOWN-REGULATION OF MHC CLASS-I ANTIGEN IN INSULINOMA CELLS CONTROLLEDBY THE R1 ELEMENT OF THE H-2 ENHANCER", Oncogene, 9(4), 1994, pp. 1195-1204

Abstract

Tumorigenesis in mice of the rat insulin promoter [RIP]-simian virus 40 tumor antigen [SV40 Tag] transgenic lineages, RIP1-Tag2 and RIP1-Tag4, is a process initiated by expression of SV40 Tag in pancreatic beta cells, evolution of islet cell hyperplasia and insulinoma appearance. Analysis of major histocompatibility complex [MHC] class I gene expression during this process revealed a normal level of MHC class I molecules at the surface of pancreatic islet cells of RIP1-Tag4 mice, while hyperplastic islets from the same mice contained cells expressing a normal level and cells expressing a low level of MHC class I antigen. Insulinomas themselves expressed very low levels or no MHC class I gene product. Thus, down-regulation of MHC class I gene appears to accompany tumor progression of SV40 Tag-transformed beta islet cells. MHC class I antigen expression in a series of clonally derived cell lines ofbeta cell origin from different SV40 Tag-induced insulinomas ranged from quite low to undetectable, although expression was inducible by interferon-gamma. Nuclear run-on and transient transfection analyses indicated that expression of the MHC class I gene in these cells is controlled at the transcriptional level, and that the decreased expression is paralleled by reduced binding of transcription factors to the R1 element of the H-2 enhancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:34:56