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Titolo:
NUCLEAR PROTEINS BINDING TO A NOVEL TARGET SEQUENCE WITHIN THE RECOMBINATION HOTSPOT REGIONS OF BCL-2 AND THE IMMUNOGLOBULIN-D(H) GENE FAMILY
Autore:
AOKI K; NAKAHARA K; IKEGAWA C; SETO M; TAKAHASHI T; MINOWADA J; STROMINGER JL; MAZIARZ RT; KASAI M;
Indirizzi:
NATL INST HLTH,DEPT IMMUN,1-23-1 TOYAMA,SHINJUKU KU TOKYO 162 JAPAN NATL INST HLTH,DEPT IMMUN,1-23-1 TOYAMA,SHINJUKU KU TOKYO 162 JAPAN UNIV TOKYO,DEPT INTERNAL MED 1,BUNKYO KU TOKYO 113 JAPAN KYORIN UNIV,SCH MED,DEPT CLIN PATHOL MITAKA TOKYO 181 JAPAN AICHI CANC CTR,CHEMOTHERAPY LAB NAGOYA AICHI 464 JAPAN AICHI CANC CTR,IMMUNOL LAB,CHIYODA KU NAGOYA AICHI 464 JAPAN HAYASHIBARA BIOCHEM LABS INC,FUJISAKI CELL CTR OKAYAMA 702 JAPAN HARVARD UNIV,DEPT BIOCHEM & MOLEC BIOL CAMBRIDGE MA 02138 OREGON HLTH SCI UNIV,DIV HEMATOL ONCOL PORTLAND OR 97201 VAMC PORTLAND OR 97207
Titolo Testata:
Oncogene
fascicolo: 4, volume: 9, anno: 1994,
pagine: 1109 - 1115
SICI:
0950-9232(1994)9:4<1109:NPBTAN>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL LEUKEMIA; CHROMOSOMAL BREAKPOINT; FOLLICULAR LYMPHOMA; DNA-REPLICATION; TRANSLOCATION; T(14-18); MECHANISM; CONSENSUS; NEOPLASMS; CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
K. Aoki et al., "NUCLEAR PROTEINS BINDING TO A NOVEL TARGET SEQUENCE WITHIN THE RECOMBINATION HOTSPOT REGIONS OF BCL-2 AND THE IMMUNOGLOBULIN-D(H) GENE FAMILY", Oncogene, 9(4), 1994, pp. 1109-1115

Abstract

The chromosomal breakpoints of follicular lymphomas carrying the t(14;18)(q32;q21) are known to be clustered within a 150-bp region in the major breakpoint region (mbr) of the Bc1-2 oncogene. We have demonstrated that nuclear proteins specifically bind to a novel target sequencewithin this 150-bp region and a region of Dxp genes, members of the immunoglobulin (Ig) diversity (D(H)) gene family. One protein, designated BCLF-1, appears to be specifically expressed in lymphoid lineage cells. Two other proteins, BCLF-2 and -3, bind only to the complementarysingle strand of the target sequence. The manner in which these proteins interact with the target sequence is similar to the interaction ofthe ReHF-1 and -2 proteins to the signal-like sequence at the chromosomal breakpoint junctions in patients with the t(8;14)(q24;q11) and t(1;14)(p32;q11) translocations. It was further suggested that the BCLF-1 is quite similar to or identical to the ReHF-1. It is therefore hypothesized that these conserved target sequences found in recombination hotspot regions may define novel sequence motifs recognized by two classes of DNA binding proteins. One class of DNA binding proteins is specifically expressed in lymphoid cells while the other class binds to the complementary single strand DNA. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 01:23:22