Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INCREASED TISSUE FACTOR PATHWAY INHIBITOR LEVELS IN UREMIC PATIENTS ON REGULAR HEMODIALYSIS
Autore:
KARIO K; MATSUO T; YAMADA T; MATSUO M;
Indirizzi:
480-2 IKUHA TSUNA HYOGO 65616 JAPAN HYOGO PREFECTURAL AWAJI HOSP,DEPT INTERNAL MED SUMOTO HYOGO JAPAN AWAJI HOKUTAN PUBL CLIN TSUNA HYOGO JAPAN
Titolo Testata:
Thrombosis and haemostasis
fascicolo: 3, volume: 71, anno: 1994,
pagine: 275 - 279
SICI:
0340-6245(1994)71:3<275:ITFPIL>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-VII HYPERACTIVITY; SYNTHETIC THROMBIN INHIBITOR; DEPENDENT BLOOD-COAGULATION; CHROMOGENIC SUBSTRATE ASSAY; ANTITHROMBIN-III; PLASMA; HEPARIN; THROMBOMODULIN; FIBRINOLYSIS; IMMUNOASSAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
K. Kario et al., "INCREASED TISSUE FACTOR PATHWAY INHIBITOR LEVELS IN UREMIC PATIENTS ON REGULAR HEMODIALYSIS", Thrombosis and haemostasis, 71(3), 1994, pp. 275-279

Abstract

We investigated tissue factor pathway inhibitor (TFPI) levels in 44 non-dialysis uremic patients and 36 chronic dialysis patients, as well as the changes of TFPI levels during hemodialysis sessions using heparin (n = 14), low molecular weight heparin (n = 7), nafamostat mesilate(n = 5), and argatroban (n = 2). In non-dialysis uremic patients, TFPI levels increased (mean +/- SD: 178 +/- 37% of control pooled plasma)along with the impairment of renal function. In chronic hemodialysis patients, TFPI levels were even higher (265 +/- 72%) before dialysis, but did not depend on the etiology of renal failure (diabetic or non-diabetic), the interval between dialysis sessions (twice or three timesa week), and the duration of hemodialysis. During hemodialysis sessions using heparin, TFPI levels increased 1.2- to 3.5-fold compared withthe level before hemodialysis and the degree of increase in TFPI was correlated with the heparin concentration (r = 0.648, p = 0.0001, n = 29). During dialysis sessions using low molecular weight heparin, TFPIlevels also increased, but the change was less marked than during dialysis with heparin. TFPI levels did not change during dialysis sessions using nafamostat mesilate or argatroban. In conclusion, TFPI levels were increased by renal failure and by long-term repeated injection ofheparin, but the hemodialysis procedure itself did not alter the TFPIlevel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:49:42