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Titolo:
APPLICATION OF RADIORECEPTOR ASSAYS FOR SYSTEMATIC TOXICOLOGICAL ANALYSIS .2. THEORETICAL CONSIDERATIONS AND EVALUATION
Autore:
ENSING K; BOSMAN IJ; EGBERTS ACG; FRANKE JP; DEZEEUW RA;
Indirizzi:
UNIV GRONINGEN,CTR PHARM,DEPT ANALYT CHEM & TOXICOL,A DEUSINGLAAN 2 9713 AW GRONINGEN NETHERLANDS
Titolo Testata:
Journal of pharmaceutical and biomedical analysis
fascicolo: 1, volume: 12, anno: 1994,
pagine: 59 - 63
SICI:
0731-7085(1994)12:1<59:AORAFS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Keywords:
RADIORECEPTOR ASSAYS; SYSTEMATIC TOXICOLOGICAL ANALYSIS; SCREENING; BENZODIAZEPINE; ANTICHOLINERGIC; ANTIHISTAMINIC; IDENTIFICATION; THERAPEUTIC DRUG MONITORING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
K. Ensing et al., "APPLICATION OF RADIORECEPTOR ASSAYS FOR SYSTEMATIC TOXICOLOGICAL ANALYSIS .2. THEORETICAL CONSIDERATIONS AND EVALUATION", Journal of pharmaceutical and biomedical analysis, 12(1), 1994, pp. 59-63

Abstract

In this paper the applicability ot radioreceptor assays tor systematic toxicological analysis will be evaluated on a theoretical basis as well as on the basis of the outcomes of the analysis of a large number of urine samples collected after administration of a selected number of drugs to healthy volunteers and patients. Many drugs and other substances of toxicological relevance exert their action through an interaction with one or more receptor (sub)types. Whether the number of persons are using particular drugs intentionally of unintentionally, radioreceptor assays can be a useful tool for systematic toxicological analysis in that they can be applied to the identification ot entire pharmacological classes of substances as well as pharmacologically active metabolites. In part 1 of this paper detailed procedures for radioreceptor assays for benzodiazepines, anticholinergics and antihistaminics have Deen described in detail in order to illustrate not only the potentials but also the limitations of assay conditions. Fifteen drugs were administered to patients and volunteers and urine samples were collected and determined with the three radioreceptor assays. The results ot this study underline the theoretical applicability ot receptor assays in systematic toxicological analysis though sample pretreatment procedures may contribute to an improvement in sensitivity and applicabilityto other biofluids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:03:28