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Titolo:
APPLICATION OF RADIORECEPTOR ASSAYS FOR SYSTEMATIC TOXICOLOGICAL ANALYSIS .1. PROCEDURES FOR RADIORECEPTOR ASSAYS FOR ANTIHISTAMINICS, ANTICHOLINERGICS AND BENZODIAZEPINES
Autore:
ENSING K; BOSMAN IJ; EGBERTS ACG; FRANKE JP; DEZEEUW RA;
Indirizzi:
UNIV GRONINGEN,CTR PHARM,DEPT ANALYT CHEM & TOXICOL,A DEUSINGLAAN 2 9713 AW GRONINGEN NETHERLANDS
Titolo Testata:
Journal of pharmaceutical and biomedical analysis
fascicolo: 1, volume: 12, anno: 1994,
pagine: 53 - 58
SICI:
0731-7085(1994)12:1<53:AORAFS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG; BINDING; LIGAND; BRAIN;
Keywords:
RADIORECEPTOR ASSAYS; SYSTEMATIC TOXICOLOGICAL ANALYSIS; SCREENING; BENZODIAZEPINE; ANTICHOLINERGIC; ANTIHISTAMINIC; FLUNITRAZAPEM; N-METHYLSCOPOLAMINE; MEPYRAMINE; THERAPEUTIC DRUG MONITORING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
K. Ensing et al., "APPLICATION OF RADIORECEPTOR ASSAYS FOR SYSTEMATIC TOXICOLOGICAL ANALYSIS .1. PROCEDURES FOR RADIORECEPTOR ASSAYS FOR ANTIHISTAMINICS, ANTICHOLINERGICS AND BENZODIAZEPINES", Journal of pharmaceutical and biomedical analysis, 12(1), 1994, pp. 53-58

Abstract

Radioreceptor assays can be a useful tool for systematic toxicological analysis in that they can be applied for the detection of an entire pharmacological class of drugs. In the present paper procedures for radioreceptor assays for benzodiazepines, anticholinergics and antihistaminics have been described in detail. The development of the assay forantihistaminics in urine is given in order to illustrate the prerequisites for these types of assays with regard to the incubation conditions. In part 2 the applicability of the three assays for systematic toxicological analysis will be evaluated on the basis of testing a large number of urine samples after administration of a selected number of drugs to healthy volunteers and patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 07:21:56