Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DEVELOPMENT OF A STRAIN OF RABBITS WITH CONGENITAL SIMPLE NONSYNDROMIC CORONAL SUTURE SYNOSTOSIS .2. SOMATIC AND CRANIOFACIAL GROWTH-PATTERNS
Autore:
MOONEY MP; LOSKEN HW; SIEGEL MI; LALIKOS JF; LOSKEN A; BURROWS AM; SMITH TD;
Indirizzi:
UNIV PITTSBURGH,DEPT ANAT & HISTOL,619 SALK HALL PITTSBURGH PA 15261 UNIV PITTSBURGH,DEPT ANTHROPOL PITTSBURGH PA 15261 UNIV PITTSBURGH,DIV PLAST & RECONSTRUCT SURG PITTSBURGH PA 15261 CHILDRENS HOSP PITTSBURGH PA 15213
Titolo Testata:
The Cleft palate-craniofacial journal
fascicolo: 1, volume: 31, anno: 1994,
pagine: 8 - 16
SICI:
1055-6656(1994)31:1<8:DOASOR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL CRANIOSYNOSTOSIS;
Keywords:
BRACHYCEPHALY; CONGENITAL; CORONAL SUTURE; CRANIOFACIAL GROWTH; CRANIOSYNOSTOSIS; PLAGIOCEPHALY; RABBITS; SOMATIC GROWTH; SYNOSTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
M.P. Mooney et al., "DEVELOPMENT OF A STRAIN OF RABBITS WITH CONGENITAL SIMPLE NONSYNDROMIC CORONAL SUTURE SYNOSTOSIS .2. SOMATIC AND CRANIOFACIAL GROWTH-PATTERNS", The Cleft palate-craniofacial journal, 31(1), 1994, pp. 8-16

Abstract

In the March 1993 issue of The Cleft Palate-Craniofacial Journal we reported a female rabbit born in our laboratory with complete bilateralcoronal suture (CS) synostosis. This follow-up study presents our attempts to breed the animal and establish a strain of craniosynostotic rabbits. The second part of this study presents longitudinal somatic and craniofacial growth data in offspring with coronal suture synostosis. Serial growth data from 72 animals were collected for the present study. The sample consisted of 11 animals (10 offspring and the originalfemale) with complete nonsyndromic unilateral (plagiocephalic) or bilateral (brachycephalic) CS synostosis, 19 animals with partial CS synostosis, and 42 unaffected control litter mates. At 10 days of age, allanimals had radiopaque amalgam markers placed on either side of the frontonasal, coronal, anterior lambdoidal, and sagittal sutures. Body weights and serial lateral and dorsoventral head radiographs were takenat 1.5 (10 days), 6, 12, and 18 weeks of age. All animals showed similar body weights at 1.5 weeks of age, while completely synostosed animals exhibited a slight (about 12%), but significantly (p < .001) lowered body weight by 18 weeks of age. Results revealed that by 1.5 weeks of age the completely synostosed animals already exhibited brachycephalic cranial vaults, mid-facial hypoplasia, and increased flattening ofthe cranial base compared to unaffected siblings. This pattern continued through 18 weeks of age, with the partially synostosed animals exhibiting intermediate morphologies. Compensatory overgrowths were notedprimarily at the sagittal and frontonasal sutures, especially for completely synostosed animals. Findings revealed that the craniosynostotic rabbits followed predictable compensatory craniofacial growth patterns and exhibited secondary deformities similar to those reported for cases of human coronal suture synostosis. Such findings support continued efforts at developing this model to help understand, in part, the etiopathogenesis of this condition in human populations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:41:49