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Titolo:
GLUTAMATE-STIMULATED PHOSPHATIDYLINOSITOL METABOLISM IN THE AVIAN COCHLEAR NUCLEUS
Autore:
ZIRPEL L; NATHANSON NM; RUBEL EW; HYSON RL;
Indirizzi:
UNIV WASHINGTON,SCH MED,DEPT PHYSIOL & BIOPHYS,SJ-40 SEATTLE WA 98195 UNIV WASHINGTON,SCH MED,DEPT PHYSIOL & BIOPHYS SEATTLE WA 98195 UNIV WASHINGTON,SCH MED,DEPT PHARMACOL SEATTLE WA 98195 UNIV WASHINGTON,VIRGINIA MERILL BLOEDEL HEARING RES CTR SEATTLE WA 98195
Titolo Testata:
Neuroscience letters
fascicolo: 1-2, volume: 168, anno: 1994,
pagine: 163 - 166
SICI:
0304-3940(1994)168:1-2<163:GPMITA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID RECEPTOR; CEREBRAL CORTICAL SLICES; D-ASPARTATE RECEPTORS; STEM AUDITORY-SYSTEM; CYCLIC-AMP FORMATION; SYNAPTIC TRANSMISSION; HIPPOCAMPAL-NEURONS; STRIATAL NEURONS; NMDA RECEPTORS; G-PROTEIN;
Keywords:
METABOTROPIC; IP3; DEAFFERENTATION; AUDITORY SYSTEM; ACPD; NUCLEUS MAGNOCELLULARIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
L. Zirpel et al., "GLUTAMATE-STIMULATED PHOSPHATIDYLINOSITOL METABOLISM IN THE AVIAN COCHLEAR NUCLEUS", Neuroscience letters, 168(1-2), 1994, pp. 163-166

Abstract

This study examined the ability of the excitatory amino acid glutamate and its analogs to stimulate phosphatidylinositol metabolism in isolated cochlear nucleus tissue from young chicks. In the presence of lithium chloride, glutamate and (+/-)-1-aminocyclopentyl-trans-1,3-dicarboxylate (ACPD) stimulated the formation of inositol phosphates to levels significantly above unstimulated control levels. Unexpectedly, quisqualate did not stimulate inositol phosphates formation. The N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-5-phosphonovalerate (APV), the ionotropic kainate/quisqualate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and the putative metabotropic glutamate receptor antagonist 2-amino-3-phosphonopropionate (AP3) had no effect on the glutamate stimulated formation of inositol phosphates. We conclude that a metabotropic glutamate receptor is present on cochlear nucleus neurons of posthatch chicks and is able to stimulate formation of inositol phosphates.

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Documento generato il 30/11/20 alle ore 20:00:39