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Titolo:
LINKAGE DISEQUILIBRIA AT THE D-2 DOPAMINE-RECEPTOR LOCUS (DRD2) IN ALCOHOLICS AND CONTROLS
Autore:
SUAREZ BK; PARSIAN A; HAMPE CL; TODD RD; REICH T; CLONINGER CR;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,4940 CHILDRENS PL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT GENET ST LOUIS MO 63110
Titolo Testata:
Genomics
fascicolo: 1, volume: 19, anno: 1994,
pagine: 12 - 20
SICI:
0888-7543(1994)19:1<12:LDATDD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISEASE ASSOCIATIONS; ALLELIC ASSOCIATION; CONTINGENCY-TABLES; DNA POLYMORPHISM; GENE DRD2; INHERITANCE; POPULATION; MECHANISMS; EXPRESSION; DISORDERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
B.K. Suarez et al., "LINKAGE DISEQUILIBRIA AT THE D-2 DOPAMINE-RECEPTOR LOCUS (DRD2) IN ALCOHOLICS AND CONTROLS", Genomics, 19(1), 1994, pp. 12-20

Abstract

Because of its central role in the neuromodulation of appetitive behaviors, the D-2 dopamine receptor gene (DRD2) has received considerablescrutiny as a possible candidate that may affect susceptibility to addictive behaviors-especially alcoholism. Association studies that compare the frequencies of anonymous restriction fragment length polymorphisms (RFLPs) in alcoholics and controls have yielded equivocal results, suggesting that any role played by this receptor will account for only part of the variation. Since these RFLPs are not located in coding regions, the hypothesis has been advanced that the association seen insome studies results from linkage disequilibrium between these markers and one or more functional DRD2 alleles that affect susceptibility. To test this hypothesis, we have assayed four DRD2 RFLPs that span coding regions as well. as a 3' flanking RFLP in an expanded sample of 88unrelated Caucasian alcoholics and 89 unrelated race-matched controls. No significant difference for any RFLP frequency between these samples was observed, although for one marker (phD2-244), the alcoholic sample showed a significant departure from the Hardy-Weinberg equilibrium. The pattern of pairwise composite disequilibrium coefficients is broadly similar in the two samples, although when the five-marker haplotype frequencies are compared, a significant difference is revealed, This difference appears to be due to greater linkage disequilibrium of the control sample. These results do not support the involvement of the DRD2 region in the etiology of alcoholism. (C) 1994 Academic Press, Inc.

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Documento generato il 09/08/20 alle ore 22:53:40