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Titolo:
THE LOSS OF E-CADHERIN MESSENGER-RNA TRANSCRIPTS IN RAT PROSTATIC TUMORS IS ACCOMPANIED BY INCREASED EXPRESSION OF MESSENGER-RNA TRANSCRIPTS ENCODING FIBRONECTIN AND ITS RECEPTOR
Autore:
MACCALMAN CD; BRODT P; DOUBLET JD; JEDNAK R; ELHILALI MM; BAZINET M; BLASCHUK OW;
Indirizzi:
ROYAL VICTORIA HOSP,UROL RES LAB,687 PINE AVE W MONTREAL H3A 1A1 QUEBEC CANADA MCGILL UNIV,ROYAL VICTORIA HOSP,DEPT SURG MONTREAL H3A 1A1 QUEBEC CANADA
Titolo Testata:
Clinical & experimental metastasis
fascicolo: 2, volume: 12, anno: 1994,
pagine: 101 - 107
SICI:
0262-0898(1994)12:2<101:TLOEMT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULES; INTEGRIN RECEPTOR; INVASION; CANCER; INVITRO;
Keywords:
CADHERINS; CANCER; COPENHAGEN RAT; FIBRONECTIN; INTEGRINS; PROSTATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
C.D. Maccalman et al., "THE LOSS OF E-CADHERIN MESSENGER-RNA TRANSCRIPTS IN RAT PROSTATIC TUMORS IS ACCOMPANIED BY INCREASED EXPRESSION OF MESSENGER-RNA TRANSCRIPTS ENCODING FIBRONECTIN AND ITS RECEPTOR", Clinical & experimental metastasis, 12(2), 1994, pp. 101-107

Abstract

We compared the levels of mRNA transcripts encoding E-cadherin, N-cadherin, beta1 integrin subunit, alpha5 integrin subunit and fibronectinin the normal rat prostate gland, as well as in tumors derived from three invasive sublines (G, MatLyLu, AT-2) of the Dunning R-3227 rat prostatic adenocarcinoma. E-cadherin mRNA transcripts were only detectable in total RNA extracts prepared from normal rat prostates, whereas N-cadherin mRNA transcripts were only found in normal rat brains. In contrast, the mRNA transcripts encoding the beta1 integrin subunit, alpha5 integrin subunit and fibronectin were all elevated in the tumors, as compared to the levels of these transcripts in normal tissues. Our results suggest that there is an inverse correlation between cadherin and integrin mRNA levels in rat prostatic tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:04:42