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Titolo:
FAMILIAL TESTOTOXICOSIS IN A CHINESE FAMILY
Autore:
LIM YJ; LOW LCK;
Indirizzi:
UNIV HONG KONG,QUEEN MARY HOSP,DEPT PAEDIAT HONG KONG HONG KONG UNIV HONG KONG,QUEEN MARY HOSP,DEPT PAEDIAT HONG KONG HONG KONG
Titolo Testata:
European journal of pediatrics
fascicolo: 4, volume: 153, anno: 1994,
pagine: 241 - 244
SICI:
0340-6199(1994)153:4<241:FTIACF>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDEPENDENT PRECOCIOUS PUBERTY; SEXUAL PRECOCITY; KETOCONAZOLE; THERAPY; LEYDIG; SPIRONOLACTONE; GENERATIONS; MECHANISM;
Keywords:
TESTOTOXICOSIS; PRECOCIOUS PUBERTY; SUPPRESSED GONADOTROPINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
Y.J. Lim e L.C.K. Low, "FAMILIAL TESTOTOXICOSIS IN A CHINESE FAMILY", European journal of pediatrics, 153(4), 1994, pp. 241-244

Abstract

We report two cases of 'familial testotoxicosis' in a family of Southern Chinese descent. The proband, an 8-year 4-month-old boy and his 35-year-old father both presented with early sexual development. In bothcases the testicular volume was only 6 ml despite fully developed secondary sexual characteristics. Both patients had adult testosterone concentrations but a suppressed gonadotrophin response to gonadotrophin-releasing hormone The suppressed gonadotrophin response to gonadotrophin-releasing hormone in the father suggests that autonomous gonadal production of sex steroid by the testes can persist well into adult lifein some patients with familial testotoxicosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:26:44