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Titolo:
FUSARIUM INFECTIONS IN IMMUNOCOMPROMISED PATIENTS - CASE-REPORTS AND LITERATURE-REVIEW
Autore:
RABODONIRINA M; PIENS MA; MONIER MF; GUEHO E; FIERE D; MOJON M;
Indirizzi:
UNIV CLAUDE BERNARD LYON 1,DEPT PARASITOL & MYCOL,8 AVE ROCKEFELLER F-69373 LYON 08 FRANCE HOP EDOUARD HERRIOT,SERV HEMATOL F-69437 LYON 03 FRANCE INST PASTEUR,UNITE MYCOL F-75724 PARIS 15 FRANCE
Titolo Testata:
European journal of clinical microbiology & infectious diseases
fascicolo: 2, volume: 13, anno: 1994,
pagine: 152 - 161
SICI:
0934-9723(1994)13:2<152:FIIIP->2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; LIPOSOMAL AMPHOTERICIN-B; LEUKEMIC PATIENT; APLASTIC-ANEMIA; SOLANI INFECTION; FUNGAL INFECTION; CHILD; HOST; HYALOHYPHOMYCOSIS; MONILIFORME;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
M. Rabodonirina et al., "FUSARIUM INFECTIONS IN IMMUNOCOMPROMISED PATIENTS - CASE-REPORTS AND LITERATURE-REVIEW", European journal of clinical microbiology & infectious diseases, 13(2), 1994, pp. 152-161

Abstract

Five cases are reported of Fusarium infection in patients with aplasia following chemotherapy of leukemia. The clinical signs, diagnosis and course of the infection during treatment are outlined and discussed in conjunction with the characteristics of other cases already reported in the literature. Sixty-three cases of Fusarium infection have beenreported in immunocompromised patients, 44 cases since 1985. These included patients with hematological malignancies (58 cases), especiallyacute leukemia (43 cases). The main sites of infection were the skin (46 cases), blood (28 cases) and lungs (13 cases). The infection was mostly diagnosed by means of skin biopsy but also by means of positive blood cultures. Forty-three strains were identified, 19 of which were Fusarium solani. Amphotericin B treatment was given in 55 cases, oftencombined with other antifungal agents, leukocyte transfusions or granulocyte-macrophage-colony stimulating factor. The outcome was fatal in36 of the 63 cases reported, often due to resistance of the strain toantifungal agents, particularly amphotericin B (20 of 33 strains tested). The most important risk factor seems to be profound and prolongedaplasia. Deep mycoses due to Fusarium species thus pose an important problem and are occurring in increasing numbers in immunocompromised patients. Treatment of these infections is difficult and the prognosis is poor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:55:41