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Titolo:
ADRENAL ANDROGENS AND TESTOSTERONE AS CORONARY RISK-FACTORS IN THE HELSINKI HEART-STUDY
Autore:
HAUTANEN A; MANTTARI M; MANNINEN V; TENKANEN L; HUTTUNEN JK; FRICK MH; ADLERCREUTZ H;
Indirizzi:
UNIV HELSINKI,DEPT CLIN CHEM,HAARTMANINKATU 4 SF-00290 HELSINKI 29 FINLAND UNIV HELSINKI,DEPT MED 1 SF-00290 HELSINKI 29 FINLAND NATL PUBL HLTH INST HELSINKI FINLAND UNIV TAMPERE,DEPT PUBL HLTH TAMPERE FINLAND
Titolo Testata:
Atherosclerosis
fascicolo: 2, volume: 105, anno: 1994,
pagine: 191 - 200
SICI:
0021-9150(1994)105:2<191:AAATAC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE BINDING GLOBULIN; SERUM DEHYDROEPIANDROSTERONE SULFATE; DENSITY-LIPOPROTEIN CHOLESTEROL; ENDOGENOUS SEX-HORMONES; CARDIOVASCULAR-DISEASE; ESSENTIAL HYPERTENSION; ARTERY DISEASE; DEHYDROISOANDROSTERONE SULFATE; PLASMA DEHYDROEPIANDROSTERONE; POSTMENOPAUSAL WOMEN;
Keywords:
STEROIDS; CORTISOL; ANDROGENS; LIPOPROTEINS; CORONARY RISK FACTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
A. Hautanen et al., "ADRENAL ANDROGENS AND TESTOSTERONE AS CORONARY RISK-FACTORS IN THE HELSINKI HEART-STUDY", Atherosclerosis, 105(2), 1994, pp. 191-200

Abstract

We investigated the role of adrenal androgens, cortisol, testosteroneand sex-hormone binding globulin (SHBG) as coronary risk factors using a nested case-control design. The study population consisted of 62 cases with cardiac endpoints and 97 controls on placebo during the last4 years in the Helsinki Heart Study. Serum concentrations of dehydroepiandrosterone, dehydroepiandrosterone sulfate (DHEAS), androstenedione, androstanediol glucuronide, cortisol, testosterone, and SHBG at thefirst annual visit of the 5-year study period were determined by radioimmunoassays. The only significant difference was found in DHEAS, with cases having higher levels than controls (P < 0.04). DHEAS levels were positively associated with smoking (P < 0.001), alcohol consumption(P < 0.04) and triglyceride levels (P < 0.002) and with systolic (P <0.04) and diastolic (P < 0.006) blood pressures, and negatively associated with age (P < 0.01) and HDL-cholesterol (P < 0.03). The association between DHEAS and the CHD risk was studied using logistic regression analyses with the classical risk factors - age, smoking, blood pressure, and lipid levels - as covariates in the models. Studies of the joint effects of age and DHEAS disclosed that the risk associated with elevated DHEAS was confined to older men (odds ratio (OR) 7.3, 95% CI 2.3-23.3). A similar analysis with smoking revealed that the DHEAS-related risk was mainly found in smokers (OR 3.4, 95% CI 1.5-8.2). One possible explanation for these results is that some form of mild steroidbiosynthetic defect of the adrenals or functional adrenal hyperplasiaassociated with high DHEAS levels increases the CHD risk in this population.

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Documento generato il 19/09/20 alle ore 12:54:42