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Titolo:
ARCHITECTURAL VARIATIONS OF INDUCIBLE EUKARYOTIC PROMOTERS - PRESET AND REMODELING CHROMATIN STRUCTURES
Autore:
WALLRATH LL; LU Q; GRANOK H; ELGIN SCR;
Indirizzi:
WASHINGTON UNIV,DEPT BIOL ST LOUIS MO 63130 WASHINGTON UNIV,DEPT BIOL ST LOUIS MO 63130
Titolo Testata:
BioEssays
fascicolo: 3, volume: 16, anno: 1994,
pagine: 165 - 170
SICI:
0265-9247(1994)16:3<165:AVOIEP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOSOME POSITIONING SEQUENCES; I HYPERSENSITIVE SITES; TUMOR VIRUS PROMOTER; DNASE-I; DROSOPHILA-MELANOGASTER; ACTIVE CHROMATIN; SACCHAROMYCES-CEREVISIAE; GLUCOCORTICOID RECEPTOR; PHO5 PROMOTER; YEAST;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
L.L. Wallrath et al., "ARCHITECTURAL VARIATIONS OF INDUCIBLE EUKARYOTIC PROMOTERS - PRESET AND REMODELING CHROMATIN STRUCTURES", BioEssays, 16(3), 1994, pp. 165-170

Abstract

The DNA in a eukaryotic nucleus is packaged into a nucleosome array, punctuated by variations in the regular pattern. The local chromatin structure of inducible genes appears to fall into two categories: preset and remodeling. Preset genes are those in which the binding sites for trans-acting factors are accessible (i.e. in a non-nucleosomal, DNase I hypersensitive configuration) prior to activation. In response to the activation signal, positive factors bind to cia-acting regulatory elements and trigger transcription with no major alterations in the chromatin structure of the promoter region. In contrast, remodeling genes are those in which some of the required cia-acting regulatory elements are packaged into nucleosomes. The nucleosomes must be perturbed inresponse to an activation signal in order for the trans-acting factors to gain access to cia-acting elements; a chromatin remodeling process which forms DNase I hypersensitive sites must occur. In both cases, precise positioning of nucleosomes along the promoter region of a geneappears to be critical for appropriate regulation of expression.

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Documento generato il 02/04/20 alle ore 12:33:12