Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PROMOTER TARGETING BY ADENOVIRUS-E1A THROUGH INTERACTION WITH DIFFERENT CELLULAR DNA-BINDING DOMAINS
Autore:
LIU F; GREEN MR;
Indirizzi:
HARVARD UNIV,DEPT BIOCHEM & MOLEC BIOL,7 DIVIN AVE CAMBRIDGE MA 02138 UNIV MASSACHUSETTS,MED CTR,PROGRAM MOLEC MED WORCESTER MA 01605
Titolo Testata:
Nature
fascicolo: 6471, volume: 368, anno: 1994,
pagine: 520 - 525
SICI:
0028-0836(1994)368:6471<520:PTBATI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
EUKARYOTIC TRANSCRIPTIONAL ACTIVATORS; RETINOBLASTOMA GENE-PRODUCT; E1A PROTEINS; MAMMALIAN-CELLS; FACTOR FAMILY; TRANSACTIVATION; ELEMENT; IDENTIFICATION; TRANSFORMATION; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
F. Liu e M.R. Green, "PROMOTER TARGETING BY ADENOVIRUS-E1A THROUGH INTERACTION WITH DIFFERENT CELLULAR DNA-BINDING DOMAINS", Nature, 368(6471), 1994, pp. 520-525

Abstract

A puzzling property of the transcriptional activators encoded by several animal viruses is their ability to function promiscuously. The adenovirus E1a protein, for example, stimulates transcription of adenoviral genes as well as a wide variety of other viral and cellular genes. We show that E1a can interact with several classes of cellular DNA-binding domains and thereby be recruited to diverse promoters. Our results explain how a single protein can regulate transcription of multiple genes that lack a common promoter element.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:44:18