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Titolo:
COOLING AUGMENTS HUMAN SAPHENOUS-VEIN REACTIVITY TO ELECTRICAL-STIMULATION
Autore:
HARKER CT; BOWMAN CJ; TAYLOR LM; PORTER JM;
Indirizzi:
OREGON HLTH SCI UNIV,DEPT SURG OP 11,DIV VASC SURG,3181 SW SAM JACKSON PARK RD PORTLAND OR 97201
Titolo Testata:
Journal of cardiovascular pharmacology
fascicolo: 3, volume: 23, anno: 1994,
pagine: 453 - 457
SICI:
0160-2446(1994)23:3<453:CAHSRT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-ADRENOCEPTORS; RAYNAUDS SYNDROME; RECEPTOR RESERVE; POSTJUNCTIONAL ALPHA-1; ADRENERGIC RESPONSES; CUTANEOUS VEINS; TEMPERATURE; VASOCONSTRICTION;
Keywords:
ALPHA(2)-ADRENOCEPTORS; RAYNAUDS SYNDROME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
C.T. Harker et al., "COOLING AUGMENTS HUMAN SAPHENOUS-VEIN REACTIVITY TO ELECTRICAL-STIMULATION", Journal of cardiovascular pharmacology, 23(3), 1994, pp. 453-457

Abstract

Human saphenous veins were obtained at operation and assayed immediately (n = 10). The veins were cut into rings, suspended in organ chambers, and connected to force transducers for recording of isometric tension. One ring served as control; others were treated with either the alpha(1)-adrenoceptor antagonist prazosin (Pz, 3 x 10(-7) M) or the alpha(2)-adrenoceptor antagonist rauwolscine (Rw(1), 10(-7) M). Cooling from 37 degrees to 24 degrees C had no significant effect on the resting tone of quiescent rings. Electrical stimulation (0.2-16 Hz) caused frequency-dependent contractions in control vessels. The contractions were inhibited by Pz (p < 0.001) and by Rw (p < 0.001). In control rings, cooling potentiated contractions evoked at all frequencies. Similaraugmentations were induced by cooling in rings treated with the alpha(1)-antagonist Pz. In contrast, rings treated with Rw before being electrically stimulated showed no significant change in contractile forcewhen cooled. The data indicate that in the human saphenous vein, bothalpha(1)- and alpha(2)-adrenoceptors are innervated, contributing to contractile response evoked by neuronal excitation. Cold augments saphenous vein reactivity to endogenously released norepinephrine (NE) by an apparent increase in the responsiveness of alpha(2)-adrenoceptors to agonists. This relationship between temperature and adrenoceptor responsiveness is consistent with the hypothesized role of alpha(2)-adrenoceptors in cold-induced vasospasm.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 09:35:47