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Titolo:
MAGNETIC-RESONANCE-IMAGING OF SKELETAL-MUSCLES IN IDIOPATHIC INFLAMMATORY MYOPATHIES OF ADULTS
Autore:
REIMERS CD; SCHEDEL H; FLECKENSTEIN JL; NAGELE M; WITT TN; PONGRATZ DE; VOGL TJ;
Indirizzi:
UNIV GOTTINGEN,KLIN NEUROPHYSIOL ABT,ROBERT KOCH STR 40 D-37075 GOTTINGEN GERMANY UNIV MUNICH,MED & NEUROL KLIN,FRIEDRICH BAUR INST W-8000 MUNICH 2 GERMANY UNIV MUNICH,RADIOL KLIN & POLIKLIN W-8000 MUNICH 2 GERMANY UNIV TEXAS,SW MED CTR,DEPT RADIOL,DIV NEURORADIOL DALLAS TX 75235 UNIV MUNICH,KLINIKUM GROSSHADERN,NEUROL KLIN & POLIKLIN W-8000 MUNICH70 GERMANY
Titolo Testata:
Journal of neurology
fascicolo: 5, volume: 241, anno: 1994,
pagine: 306 - 314
SICI:
0340-5354(1994)241:5<306:MOSIII>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPUTED-TOMOGRAPHY; MR; DERMATOMYOSITIS; POLYMYOSITIS; SPECTROSCOPY; SARCOIDOSIS; MYOSITIS;
Keywords:
MYOSITIS; SKELETAL MUSCLES; MAGNETIC RESONANCE IMAGING; CREATINE KINASE ELECTROMYOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
C.D. Reimers et al., "MAGNETIC-RESONANCE-IMAGING OF SKELETAL-MUSCLES IN IDIOPATHIC INFLAMMATORY MYOPATHIES OF ADULTS", Journal of neurology, 241(5), 1994, pp. 306-314

Abstract

The purpose of the study was to describe typical MRI findings in various types of idiopathic inflammatory myopathies in adulthood and to correlate the MRI with histopathological and electromyographic findings,and the serum creatine kinase (CK) activity. A third goal was to assess the diagnostic value of the use of gadolinium-DTPA (Gd-DTPA). Fifty-eight patients (35 women, 23 men), aged 21-83 years (median age 59 years), suffering from idiopathic myositides (13 with acute and 45 chronic diseases; 25 with polymyositis, 14 with dermatomyositis, 8 with granulomatous and 11 with inclusion body myositides) were examined with MRI. Seventeen of them received an intravenous infusion of Gd-DTPA. Histopathological and MRI findings of 21 muscles of 18 patients were compared. MRI of skeletal muscles showed abnormal signal intensities in 56(96.6%) of the 58 patients. MRI abnormalities were found more often than elevated CK activity (P < 0.001). The hyperintensity of T2-weighted images was more conspicuous than on T1-weighted images in 26 (44.8%)patients, indicating oedema-like abnormalities. MRI of 50 (86.2%) patients showed fat replacement. In acute myositides, oedema-like abnormalities were more often visible and in muscle lipomatosis less often visible than in chronic diseases (P < 0.05 each). In dermatomyositis oedema-like abnormalities were more and lipomatosis less frequent than inthe other types of myositis (P < 0.005) and correlated with the acuteness of the disease. In 3 of 17 patients in whom contrast-enhanced T1-weighted images were obtained in addition to plain T1- and T2-weightedimages, T2-weighted images were more sensitive in the detection of oedema-like abnormalities than the contrast-enhanced T1-weighted images. In no patient was the opposite true. Thus, contrast-enhanced T1-weighted images did not provide more information than T2-weighted images. Nine patients with poly-, dermato- and inclusion body myositis showed clearly asymmetrical findings. Imaging of the thighs and legs was of similar sensitivity. The different types of myositides showed typical but not specific distributions of the mesenchymal abnormalities in MRI. The findings indicate that MRI of skeletal muscles in myositides can visualize the presence and distribution of oedema-like abnormalities and intramuscular lipomatosis and is suitable for the assessment of the chronicity and severity of the disease.

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Documento generato il 27/10/20 alle ore 05:24:52