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Titolo:
DETECTION OF ONCOGENE MUTATIONS IN SPUTUM PRECEDES DIAGNOSIS OF LUNG-CANCER
Autore:
MAO L; HRUBAN RH; BOYLE JO; TOCKMAN M; SIDRANSKY D;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT OTOLARYNGOL HEAD & NECK SURG,DIV HEAD& NECK CANC RES BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT OTOLARYNGOL HEAD & NECK SURG,DIV HEAD& NECK CANC RES BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT ENGN BALTIMORE MD 21205 JOHNS HOPKINS UNIV HOSP,CTR ONCOL,DEPT ONCOL BALTIMORE MD 21205 JOHNS HOPKINS UNIV HOSP,DEPT PATHOL BALTIMORE MD 21205
Titolo Testata:
Cancer research
fascicolo: 7, volume: 54, anno: 1994,
pagine: 1634 - 1637
SICI:
0008-5472(1994)54:7<1634:DOOMIS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; P53 GENE-MUTATIONS; COLORECTAL TUMORIGENESIS; TUMORS; CELLS; IDENTIFICATION; ABNORMALITIES; CARCINOMA; DELETIONS; LESIONS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
L. Mao et al., "DETECTION OF ONCOGENE MUTATIONS IN SPUTUM PRECEDES DIAGNOSIS OF LUNG-CANCER", Cancer research, 54(7), 1994, pp. 1634-1637

Abstract

The Johns Hopkins Lung Project developed an archive of sputum specimens during a randomized trial of lung cancer screening (1974-1982). We identified 15 patients from that trial who later developed adenocarcinoma of the lung. The primary lung carcinomas from 10 of these 15 patients contained either a ras or a p53 gene mutation. Using a polymerase chain reaction-based assay. stored sputum samples obtained prior to clinical diagnosis were examined for the presence of these same oncogenemutations. In 8 of 10 patients, the identical mutation identified in the primary tumor was also detected in at least one sputum sample. Theearliest detection of a clonal population of cancer cells in sputum was in a sample obtained more than 1 year prior to clinical diagnosis. These results provide the basis of a novel approach for detection of lung cancer based on the evolving molecular genetics of this disease.

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Documento generato il 27/11/20 alle ore 01:46:16