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Titolo:
THE MAGNESIUM LOADING TEST - REFERENCE VALUES IN HEALTHY-SUBJECTS
Autore:
GULLESTAD L; MIDTVEDT K; DOLVA LO; NORSETH J; KJEKSHUS J;
Indirizzi:
NATL HOSP NORWAY,MED DEPT B N-0027 OSLO 1 NORWAY FURST LAB OSLO NORWAY BAERUM HOSP,DEPT MED OSLO NORWAY
Titolo Testata:
Scandinavian journal of clinical & laboratory investigation
fascicolo: 1, volume: 54, anno: 1994,
pagine: 23 - 31
SICI:
0036-5513(1994)54:1<23:TMLT-R>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALCOHOLIC PATIENTS; DEFICIENCY; POTASSIUM; DISEASE; CALCIUM;
Keywords:
MAGNESIUM DEFICIENCY; MAGNESIUM LOADING TEST; MAGNESIUM RETENTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
L. Gullestad et al., "THE MAGNESIUM LOADING TEST - REFERENCE VALUES IN HEALTHY-SUBJECTS", Scandinavian journal of clinical & laboratory investigation, 54(1), 1994, pp. 23-31

Abstract

The magnesium loading test is a useful tool in the diagnosis of magnesium deficiency. In order to establish a reference range in normal subjects, 88 healthy men and women aged between 18 and 66 years were given 30 mmol magnesium intravenously during eight hours as a loading test, urine was collected from start of infusion for 24 h for measurement of magnesium excretion. The magnesium mean retention was 6.3 +/- 10.3%of the loading dose, and the 0.025 and 0.975 fractiles were -19.5% and 27.5%, respectively. There was no significant difference between thesexes or in the different age groups studied. There was no correlation between the magnesium retention and serum magnesium or with basal urinary magnesium excretion. An excess excretion of magnesium was observed the postload day compared to baseline, but the excretion 24 and 48 h after the magnesium loading were closely correlated, suggesting that24 h urinary sampling is sufficient. In order to examine the reproducibility of the test 23 of the subjects underwent two magnesium loadingtests 4 weeks apart. The mean difference between two repeat magnesiumloading tests was 2.0% with a SD of 8.1% and a 95% confidence interval of -1.6-5.5%. Normal saline did not affect baseline magnesium excretion. Concomitant administration of ethanol or physical exercise causedgreater variation in magnesium excretion, whereas furosemide was without effect. The 8 h magnesium loading test with 24 h urine sampling seems to be fairly reproducible, is adequate for clinical use, but the normal range is wide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 09:41:30