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Titolo:
TOXIC EFFECTS OF DIMETHYLTHIOUREA IN RATS
Autore:
BEEHLER CJ; ELY ME; RUTLEDGE KS; SIMCHUK ML; REISS OK; SHANLEY PF; REPINE JE;
Indirizzi:
WEBB WARING LUNG INST,4200 E 9TH AVE,BOX C322 DENVER CO 80262 UNIV COLORADO,HLTH SCI CTR,DEPT MED DENVER CO 80262 UNIV COLORADO,HLTH SCI CTR,DEPT PATHOL DENVER CO 80262
Titolo Testata:
The Journal of laboratory and clinical medicine
fascicolo: 1, volume: 123, anno: 1994,
pagine: 73 - 80
SICI:
0022-2143(1994)123:1<73:TEODIR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROXYL-RADICAL SCAVENGERS; INDUCED PULMONARY-EDEMA; OXIDANT LUNG INJURY; HYDROGEN-PEROXIDE; HYPEROXIC INJURY; PREVENTION; ENDOTOXIN; INVITRO; RABBITS; PLASMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
C.J. Beehler et al., "TOXIC EFFECTS OF DIMETHYLTHIOUREA IN RATS", The Journal of laboratory and clinical medicine, 123(1), 1994, pp. 73-80

Abstract

Dimethylthiourea (DMTU) is a small, highly diffusible molecule that effectively scavenges toxic oxygen metabolites in vitro and reduces oxidative injury in many biologic systems. Nonetheless, for unknown reasons, DMTU has occasionally failed to decrease damage in some systems where injury is presumed to be mediated by oxygen metabolites. We hypothesized that the inconsistent pattern of protection might partially reflect a direct toxicity of DMTU. Our results supported this premise. Wefound that rats treated with commonly used doses of highly purified DMTU had increased lung accumulation of intravenously injected iodine 125-labeled albumin (4 hours after DMTU treatment) and decreased blood glutathione levels (24 hours after DMTU treatment) when compared with saline-injected control rats. In contrast, rats treated with dimethylurea, a analog of DMTU; did not develop increased accumulation of labeled albumin in the lungs or decreased blood glutathione levels. We conclude that DMTU has intrinsically toxic effects in rats and that DMTU toxicity may at times obscure ifs protective action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 06:20:16