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Titolo:
EFFECT OF PENTOBARBITAL AND GASEOUS ANESTHETICS ON RATS SELECTIVELY BRED FOR ETHANOL SENSITIVITY
Autore:
DEITRICH RA; DRASKI LJ; BAKER RC;
Indirizzi:
UNIV COLORADO,HLTH SCI CTR,ALCOHOL RES CTR,DEPT PHARMACOL,4200 E 9TH AVE DENVER CO 80262
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 3, volume: 47, anno: 1994,
pagine: 721 - 725
SICI:
0091-3057(1994)47:3<721:EOPAGA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED CHLORIDE CHANNELS; SUBUNIT MESSENGER-RNAS; GABA-A RECEPTORS; SHORT-SLEEP MICE; BRAIN SYNAPTOSOMAL MEMBRANES; GENERAL-ANESTHETICS; XENOPUS OOCYTES; LONG-SLEEP; ELIMINATION; COMPLEX;
Keywords:
SELECTIVE BREEDING; HAS; LAS; ANESTHETICS; GENETICS; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Deitrich et al., "EFFECT OF PENTOBARBITAL AND GASEOUS ANESTHETICS ON RATS SELECTIVELY BRED FOR ETHANOL SENSITIVITY", Pharmacology, biochemistry and behavior, 47(3), 1994, pp. 721-725

Abstract

Rats have been genetically selected to have a differential hypnotic response to an acute injection of ethanol. These high alcohol sensitive(HAS) and low alcohol sensitive (LAS) rats were used to investigate commonalities of the mechanism of action of several gaseous anesthetics, pentobarbital and ethanol. Similar studies have been carried out extensively with mouse lines also differentially sensitive to ethanol (short- and long-sleep mice). Like the mice, the rats are also differentially sensitive to the two gaseous anesthetics, enflurane and isoflurane. However, in contrast to results with these mice, we find that the HAS and LAS rats are differentially sensitive to halothane and pentobarbital in the same direction as their sensitivity to ethanol. In other studies, the rats also have been found to be differentially sensitive to phenobarbital as are SS and LS mice. These results show that, by the use of these anesthetics in combination with selectively bred rodentlines, many new opportunities for dissecting the molecular mechanismsof anesthetic agents present themselves.

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Documento generato il 06/04/20 alle ore 08:33:37