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Titolo:
THE THERAPEUTIC EFFECTS OF 4-METHYLCATECHOL, A STIMULATOR OF ENDOGENOUS NERVE GROWTH-FACTOR SYNTHESIS, ON EXPERIMENTAL DIABETIC NEUROPATHY IN RATS
Autore:
HANAOKA Y; OHI T; FURUKAWA S; FURUKAWA Y; HAYASHI K; MATSUKURA S;
Indirizzi:
MIYAZAKI MED COLL,DEPT INTERNAL MED,DIV NEUROL,5200 KIHARA,KIYOTAKE CHO MIYAZAKI 88916 JAPAN GIFU PHARMACEUT UNIV,DEPT MOLEC BIOL GIFU JAPAN
Titolo Testata:
Journal of the neurological sciences
fascicolo: 1, volume: 122, anno: 1994,
pagine: 28 - 32
SICI:
0022-510X(1994)122:1<28:TTEO4A>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINAL-CORD MOTONEURONS; SCIATIC-NERVE; NEUROTROPHIC FACTORS; AXONAL-TRANSPORT; REGENERATION; PROTEIN; CATECHOLAMINES; PATHOGENESIS; CULTURE; CELLS;
Keywords:
4-METHYLCATECHOL; NERVE GROWTH FACTOR; EXPERIMENTAL DIABETIC NEUROPATHY; MOTOR NERVE CONDUCTION VELOCITY; MORPHOMETRICAL ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
Y. Hanaoka et al., "THE THERAPEUTIC EFFECTS OF 4-METHYLCATECHOL, A STIMULATOR OF ENDOGENOUS NERVE GROWTH-FACTOR SYNTHESIS, ON EXPERIMENTAL DIABETIC NEUROPATHY IN RATS", Journal of the neurological sciences, 122(1), 1994, pp. 28-32

Abstract

We investigated therapeutic effects of 4-methylcatechol (4-MC), a non-amine catechol compound, on streptozotocin (STZ)-induced diabetic neuropathy in rats. 4-MC is one of the potent stimulators of endogenous nerve growth factor (NGF) synthesis both in vitro and in vivo. Diabeticrats showed a statistically significant reduction in motor nerve conduction velocity (MNCV), mean myelinated axon diameter, and NGF contentin the sciatic nerve during the experimental period of 8 weeks. The 4-MC treatment started 4 weeks after the STZ injection resulted in significantly greater NGF content, faster MNCV, and larger mean myelinatednerve fiber diameter and axon diameter than in untreated diabetic rats. These findings suggest that a decreased NGF level in the diabetic sciatic nerves may be involved in the pathogenesis of diabetic neuropathy and that 4-MC treatment could be useful for diabetic neuropathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 20:09:25