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Titolo:
EXPRESSION OF N-CAM IN FERTILIZED PREIMPLANTATION AND PERIIMPLANTATION AND PARTHENOGENETICALLY ACTIVATED MOUSE EMBRYOS
Autore:
KIMBER SJ; BENTLEY J; CIEMERYCH M; MOLLER CJ; BOCK E;
Indirizzi:
UNIV MANCHESTER,SCH BIOL SCI,STOPFORD BLDG,OXFORD RD MANCHESTER M13 9PT ENGLAND UNIV COPENHAGEN,PANUM INST,PROT LAB DK-2200 COPENHAGEN DENMARK
Titolo Testata:
European journal of cell biology
fascicolo: 1, volume: 63, anno: 1994,
pagine: 102 - 113
SICI:
0171-9335(1994)63:1<102:EONIFP>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULE; HEPARIN-BINDING DOMAIN; RAT-BRAIN; PREIMPLANTATION EMBRYO; MONOCLONAL-ANTIBODY; SURFACE MODULATION; POLYSIALIC ACID; XENOPUS-LAEVIS; NCAM; ADULT;
Keywords:
N-CAM; MOUSE EMBRYO; CELL ADHESION; PARTHENOGENETIC DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
71
Recensione:
Indirizzi per estratti:
Citazione:
S.J. Kimber et al., "EXPRESSION OF N-CAM IN FERTILIZED PREIMPLANTATION AND PERIIMPLANTATION AND PARTHENOGENETICALLY ACTIVATED MOUSE EMBRYOS", European journal of cell biology, 63(1), 1994, pp. 102-113

Abstract

The expression of the cell adhesion molecule of the immunoglobulin family, neural cell adhesion molecule (N-CAM), in the pre and periimplantation embryo was examined by immunocytochemistry. N-CAM is expressed on unfertilized ovulated oocytes, fertilized preimplantation embryos at all stages of development and parthenogenetically activated eggs andembryos. In fertilized embryos, expression from the 4-cell stage can be partially inhibited by blocking embryonic transcription before 38 hpost human chorionic gonadotropin (hCG). Expression of N-CAM was reduced on the trophoblast of day 6 blastocysts in culture, weak on the trophoblast of embryonic outgrowths and disappears from invading trophoblast in utero. An antibody against alpha(2-8) linked polysialic acid, mAb2-2B, reacted with embryos from the 8-cell stage, and staining was similarly reduced on the trophoblast of blastocysts at the time of implantation. These results suggest a role for N-CAM in the interactions of cells of the preimplantation mammalian embryo which requires further investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 05:45:22