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Titolo:
INPUT RESPIRATORY IMPEDANCE TO ESTIMATE AIRWAY HYPERREACTIVITY IN CHILDREN - STANDARD METHOD VERSUS HEAD GENERATOR
Autore:
MARCHAL F; MAZUREK H; HABIB M; DUVIVIER C; DERELLE J; PESLIN R;
Indirizzi:
FAC MED NANCY,PHYSIOL LAB,BP 184 F-54505 VANDOEUVRE NANCY FRANCE CHU NANCY,HOP ENFANTS,EXPLORAT FONCTIONELLES PEDIAT LAB F-54000 NANCYFRANCE INSERM,U14,UNITE PHYSIOPATHOL RESP F-54511 VANDOEUVRE NANCY FRANCE CHU NANCY,HOP ENFANTS,SERV MED INFANTILE F-54000 NANCY FRANCE
Titolo Testata:
The European respiratory journal
fascicolo: 3, volume: 7, anno: 1994,
pagine: 601 - 607
SICI:
0903-1936(1994)7:3<601:IRITEA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
FORCED OSCILLATION; SHUNT;
Keywords:
AIRWAY REACTIVITY; CHILDREN; FORCED OSCILLATION; RESPIRATORY MECHANICAL IMPEDANCE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
F. Marchal et al., "INPUT RESPIRATORY IMPEDANCE TO ESTIMATE AIRWAY HYPERREACTIVITY IN CHILDREN - STANDARD METHOD VERSUS HEAD GENERATOR", The European respiratory journal, 7(3), 1994, pp. 601-607

Abstract

We previously found that a significant underestimation of respiratorymechanical impedance (Zrs) at high frequency may result from the upper airway artefact in children, when pressure is directly varied at themouth. To determine the importance of this artefact in estimating lung response to bronchomotor agents with the forced oscillation technique, input respiratory mechanical impedance was measured using 6-32 Hz pseudorandom pressure oscillations applied directly to the mouth (standard generator (SG)) and around the subject's head (head generator (HG)) in 35 children aged 2.5-13 yrs. Changes in resistance were generallylarger with HG than SG. The mean+/-SEM changes in resistance of the respiratory system (Rrs) at 20 Hz induced by acetylcholine or allergen challenge were 15+/-4% for SG and 67+/-12% for HG, and changes inducedby bronchodilators were -25+/-2% for SG, and -46+/-4% for HG (p<0.01). Challenge induced negative frequency dependence of Rrs with SG and positive frequency dependence with HG. There was significant increase in inertance after salbutamol with SG, but no significant change occurred with HG. With both methods, respiratory compliance decreased significantly after challenge. Computer simulations showed that the difference in change in Rrs induced by airway challenge with HG and SG could be explained by the effect of the upper airway wall impedance (Zuaw). Zuaw could also account for the change in inertance and compliance observed with SG, but not for the change in compliance with HC. The lattercould be reproduced by simulating unequal distribution of mechanical time constants within the lung, increased peripheral lung resistance with compliant central airways. It is suggested that the head generatormay improve the sensitivity of the forced oscillation technique in evaluating bronchomotor responses in children. The decrease in compliance induced by bronchoconstrictor challenge appears more specific of a physiological response with head generator than with standard generator.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:02:02