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Titolo:
OUTCOME OF CADAVER KIDNEY-TRANSPLANTATION IN SMALL CHILDREN
Autore:
COCHAT P; CASTELO F; GLASTRE C; MARTIN X; STAMM D; LONG D; LAVOCAT MP; HADJAISSA A; LYONNET D; FLORET D;
Indirizzi:
HOP EDOUARD HERRIOT,UNITE NEPHROL PEDIAT F-69437 LYON 03 FRANCE HOP EDOUARD HERRIOT,SERV UROL & CHIRURG TRANSPLANTAT LYON FRANCE HOP EDOUARD HERRIOT,UNITE REANIMAT PEDIAT LYON FRANCE HOP EDOUARD HERRIOT,SERV EXPLORAT FONCTIONNELLES RENALES LYON FRANCE HOP EDOUARD HERRIOT,SERV RADIOL EST LYON FRANCE UNIV CLAUDE BERNARD LYON FRANCE HOP NORD ST PRIEST JAREZ,SERV PEDIAT ST PRIEST JAREZ FRANCE
Titolo Testata:
Acta paediatrica
fascicolo: 1, volume: 83, anno: 1994,
pagine: 78 - 83
SICI:
0803-5253(1994)83:1<78:OOCKIS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEDIATRIC RENAL-TRANSPLANTATION; GRAFT-SURVIVAL; DONOR AGE; RECIPIENTS; CYCLOSPORINE; INFANTS; LESS;
Keywords:
CADAVER DONOR; CYCLOSPORINE A; INFANT; KIDNEY TRANSPLANTATION; SMALL CHILDREN; STATURAL GROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
P. Cochat et al., "OUTCOME OF CADAVER KIDNEY-TRANSPLANTATION IN SMALL CHILDREN", Acta paediatrica, 83(1), 1994, pp. 78-83

Abstract

Small children have often been reported to have poor outcome after kidney transplantation (KT). Recent reports from North America have shown that the use of living-related donors improves patient and graft survival. We report the experience in one centre of primary cadaveric KT using sequential immunosuppression in nine children aged 8-30 months and weighing 5.4-9.8 kg; donors were 0.7-12.3 years old. Four patients had pre-emptive KT and the other five were on peritoneal dialysis; themean +/- SD waiting time was 2.0 +/- 2.4 months. Perioperative care has been published previously. The surgical approach was intraperitoneal if the aorta and vena cava were used (n = 7) and extraperitoneal forcommon iliac vessels anastomosis (n = 2); the duration of surgery was3.5 +/- 0.9 h and the time for vascular anastomosis was 32 +/- 6 min. The recipients received ATG, azathioprine, prednisone and delayed administration of cyclosporin A. The patients were followed for 12-98 (median 41) months and showed good graft function (inulin clearance 63-100 ml/min/1.73 m(2)); only one child with recurrent haemolytic uraemic syndrome lost his graft three months post-transplantation and died after he had received a second graft. None of the recipients required post-transplant dialysis; arterial hypertension involved four children and was related to graft artery stenosis in two. Growth improved by 0.24+/- 0.48 SD score of height per year. Compared to earlier reports on cadaver transplantation in small children (about 40% graft survival after five years) and to the outcome of chronic peritoneal dialysis, thepresent results are better and appear to be similar to those obtainedwith living-related donor transplantation.

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Documento generato il 04/12/20 alle ore 15:23:10