Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PROTECTION BY AMYLIN OF GASTRIC-EROSIONS INDUCED BY INDOMETHACIN OR ETHANOL IN RATS
Autore:
GUIDOBONO F; PAGANI F; TICOZZI C; SIBILIA V; PECILE A; NETTI C;
Indirizzi:
UNIV MILAN,DEPT PHARMACOL CHEMOTHERAPY & MED TOXICOL,VIA VANVITELLI 32 I-20129 MILAN ITALY
Titolo Testata:
British Journal of Pharmacology
fascicolo: 4, volume: 120, anno: 1997,
pagine: 581 - 586
SICI:
0007-1188(1997)120:4<581:PBAOGI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; ISLET AMYLOID POLYPEPTIDE; ACID SECRETION; NITRIC-OXIDE; GASTROINTESTINAL-TRACT; PANCREATIC AMYLIN; BINDING-SITES; CALCITONIN; INVITRO; LESIONS;
Keywords:
AMYLIN; BRAIN; ULCERS; ETHANOL; INDOMETHACIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
F. Guidobono et al., "PROTECTION BY AMYLIN OF GASTRIC-EROSIONS INDUCED BY INDOMETHACIN OR ETHANOL IN RATS", British Journal of Pharmacology, 120(4), 1997, pp. 581-586

Abstract

1 The effect of amylin on gastric ulcers induced by oral administration of indomethacin (Indo, 20 mg kg(-1) at a dosing volume of 5 ml) or ethanol 50% (EtOH, 1 ml/rat) was investigated in conscious rats. 2 Amylin given intracerebroventricularly (0.22, 0.66 and 2.2 mu g/rat, i.c.v.) demonstrated a dose-dependent cytoprotective effect against both Indo and EtOH-induced ulcers. In contrast, amylin, given subcutaneouslyat doses effective in inhibiting acid gastric secretion (2.5, 10 and 40 mu g kg(-1), s.c.), did not show any cytoprotective effect. 3 The interaction between amylin and endogenous nitric oxide (NO) in the maintenance of gastric mucosal integrity was investigated by pretreating the rats with a selective inhibitor of NO-synthesis, N-G-nitro-L-arginine methyl ester (L-NAME, 25 and 70 mg kg(-1), s.c.). Administration ofL-NAME to rats did not significantly increase the degree of the Indo-induced ulcer index and was not able to remove the protective effect of amylin on Indo-induced ulcers, thus excluding a role for endogenous NO in mediating the protective effect of this peptide. 4 To determine whether the cytoprotective effect of amylin was mediated by endogenousprostaglandins, we studied the effect of amylin (2.2 mu g/rat, i.c.v.) on EtOH- induced ulcers in rats pretreated with Indo (10 mg kg(-1), s.c.) to inhibit prostanoid biosynthesis; Indo was injected 30 min before amylin and EtOH after a further 30 min. Pretreatment with Indo didnot significantly increase the ulcer index induced by EtOH but counteracted the ability of amylin to prevent the ulcer formation. 5 These findings suggest that amylin exerts a gastroprotective activity that isnot strictly related to inhibition of acid gastric secretion and can be partly explained through a prostaglandin-dependent mechanism mediated by receptors for the peptide in the brain. Amylin might be considered as a new brain-gut peptide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 09:17:39