Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MURINE MODELS OF POLYCYSTIC KIDNEY-DISEASE
Autore:
SCHIEREN G; PEY R; BACH J; HAFNER M; GRETZ N;
Indirizzi:
UNIV HEIDELBERG,KLINIKUM MANNHEIM,MED DEPT 5,THEODOR KUTZER UFER 1-3 D-68167 MANNHEIM GERMANY TECH UNIV APPL SCI,DEPT APPL CELL BIOL MANNHEIM GERMANY
Titolo Testata:
Nephrology, dialysis, transplantation
, volume: 11, anno: 1996, supplemento:, 6
pagine: 38 - 45
SICI:
0931-0509(1996)11:<38:MMOPK>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIETARY-PROTEIN RESTRICTION; TRANSGENIC MICE; CYSTIC-DISEASE; CPK MOUSE; GROWTH-FACTOR; EXTRACELLULAR-MATRIX; EPITHELIAL-CELLS; ANIMAL-MODELS; MESSENGER-RNA; EARLY REGION;
Keywords:
MOUSE; POLYCYSTIC KIDNEY DISEASE; TRANSGENIC MODELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
77
Recensione:
Indirizzi per estratti:
Citazione:
G. Schieren et al., "MURINE MODELS OF POLYCYSTIC KIDNEY-DISEASE", Nephrology, dialysis, transplantation, 11, 1996, pp. 38-45

Abstract

The current knowledge of human polycystic kidney disease (PKD)-its morphology as well as the current biochemical and molecular understanding of the disease-has been enormously aided by the existence of a variety of animal models. In mice, several spontaneous mutations have been identified that give rise to PKD. Furthermore, it has been possible tocreate experimental models of renal cystic disease by genetic manipulation. All these different models have been very informative in studying the role of growth hormones, cell differentiation and hyperplasia, ionic transport, oncogene expression and changes in extracellular matrix (ECM) composition during the development of PKD. Furthermore, they have allowed investigators to test different therapeutic approaches invivo. This article will review the characteristics of the most commonmurine models of PKD, some of their current uses and the future role of these animal models in the understanding of human renal cystic disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 04:53:20