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Titolo:
STRUCTURAL MOTIFS OF THE PKD1 PROTEIN
Autore:
LOHNING C; POHLSCHMIDT M; GLUCKSMANNKUIS MA; DUYK G; BORK P; SCHNEIDER MO; REEDERS ST; FRISCHAUF AM;
Indirizzi:
IMPERIAL CANC RES FUND,44 LINCOLNS INN FIELDS LONDON WC2A 3PX ENGLAND IMPERIAL CANC RES FUND LONDON WC2A 3PX ENGLAND MILLENNIUM PHARMACEUT INC CAMBRIDGE MA 02139 EUROPEAN MOL BIOL LAB D-69117 HEIDELBERG GERMANY MAX DELBRUCK CTR MOL MED D-13125 BERLIN GERMANY BRIGHAM & WOMENS HOSP,DEPT MED,DIV RENAL BOSTON MA 02115 HARVARD UNIV,SCH MED BOSTON MA 02115
Titolo Testata:
Nephrology, dialysis, transplantation
, volume: 11, anno: 1996, supplemento:, 6
pagine: 2 - 4
SICI:
0931-0509(1996)11:<2:SMOTPP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYSTIC KIDNEY-DISEASE; LEUCINE-RICH REPEATS; CARBOHYDRATE-RECOGNITION; NUCLEOTIDE-SEQUENCE; GENE; DOMAINS; ADHESION; SURFACE; GLYCOPROTEINS; DROSOPHILA;
Keywords:
CELL-CELL INTERACTION; CELL-MATRIX INTERACTION; POLYCYSTIC KIDNEY DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
C. Lohning et al., "STRUCTURAL MOTIFS OF THE PKD1 PROTEIN", Nephrology, dialysis, transplantation, 11, 1996, pp. 2-4

Abstract

The complete sequence of the polycystic kidney disease gene (PKD1) and its transcript have been described. The predicted protein is not a member of a previously described gene family, but contains several structural motifs that are present in proteins of known function. Most of these domains are present in the extracellular parts of proteins involved in interactions with other proteins and carbohydrates. The PKD1 gene product also contains potential transmembrane sequences. The molecule is likely to be involved in cell-cell or cell-matrix interactions, which is consistent with the different manifestations of polycystic kidney disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 02:36:43