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Titolo:
PREVALENCE OF HEMOCHROMATOSIS AMONG FIRST-TIME AND REPEAT BLOOD-DONORS IN NORWAY
Autore:
BELL H; THORDAL C; RAKNERUD N; HANSEN T; BOSNES V; HALVORSEN R; HEIER HE; TRY K; LEIVESTAD T; THOMASSEN Y;
Indirizzi:
AKER UNIV HOSP,HEPATOL UNIT,DEPT MED,TRONDHJEMSVEIEN 235 N-0514 OSLO NORWAY AKER UNIV HOSP,DEPT PATHOL N-0514 OSLO NORWAY ULLEVAL HOSP,DEPT IMMUNOL & TRANSFUS MED OSLO NORWAY ULLEVAL HOSP,DEPT CLIN CHEM OSLO NORWAY UNIV OSLO,NATL HOSP,INST TRANSPLANTAT IMMUNOL OSLO NORWAY NATL INST OCCUPAT HLTH OSLO NORWAY
Titolo Testata:
Journal of hepatology
fascicolo: 2, volume: 26, anno: 1997,
pagine: 272 - 279
SICI:
0168-8278(1997)26:2<272:POHAFA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
IRON-LOADING GENE; HEREDITARY HEMOCHROMATOSIS; IDIOPATHIC HEMOCHROMATOSIS; PHENOTYPIC-EXPRESSION; SERUM FERRITIN; POPULATION; OVERLOAD; SWEDEN;
Keywords:
BLOOD DONORS; FERRITIN; HEMOCHROMATOSIS; HEPATIC IRON INDEX; PREVALENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
H. Bell et al., "PREVALENCE OF HEMOCHROMATOSIS AMONG FIRST-TIME AND REPEAT BLOOD-DONORS IN NORWAY", Journal of hepatology, 26(2), 1997, pp. 272-279

Abstract

Background/Aims: The observed prevalence of hemochromatosis has ranged considerably from 0.05 to 0.37% in studies requiring liver biopsy. We aimed to study the prevalence of genetic hemochromatosis among Norwegian blood donors. Methods: We studied 10552 healthy blood donors (5312 women and 5240 men) using serum ferritin as a screening parameter. If serum ferritin concentration was greater than or equal to 100 mu g/lin women and greater than or equal to 200 mu g/l in men, serum iron and transferrin (measured as total iron binding capacity = TIBC) were measured, Blood donors who repeatedly had a transferrin saturation above 40% and a ferritin concentration above these limits were referred toa hepatologist (H.B.). Results: Serum ferritin was greater than or equal to 100 mu g/l in 94/5312 (1.8%) women and greater than or equal to200 mu l in 79/5240 (1.5%) men. Of these, 37 persons had a serum ferritin concentration above 100 mu g/l (females) or above 200 mu g/l (males) and a transferrin saturation above 40%. Nineteen of them (13 men and 6 women, median age 36 years, range 28-68) were identified as having hemochromatosis on the basis of increased hepatic iron index, Serum ferritin ranged from 111 to 1980 mu g/l (median 357 mu g/l and transferrin saturation from 50 to 100% (median 92%), hepatic iron from 48 to 471 mu mol/g dry weight (median 118 mu mol/g) and hepatic iron index from 1.5 to 12.1 (median 3.0), One person had cirrhosis and none had diabetes, The prevalence of hemochromatosis was significantly higher among first-time blood donors (12 out of 3500 [3.4/1000]) compared with repeat donors (7 out of 7052 [1/1000]), p < 0.005. Conclusions: The observed prevalence of hemochromatosis in Norwegian first-time blood donors of 0.34% is comparable to recently observed prevalences in other studies, However, the use of serum ferritin as a first-step screening tool may have failed to detect hemochromatosis in the early stage where iron overload has not yet occurred.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 06:44:15