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Titolo:
SEQUENTIAL STUDY OF SERUM GLYCOPROTEIN FUCOSYLATION IN ACUTE HEPATITIS
Autore:
SETA N; GAYNO S; JEZEQUELCUER M; TOUEG ML; ERLINGER S; DURAND G;
Indirizzi:
HOP BICHAT,BIOCHIM LAB A,46 RUE HENRI HUCHARD F-75877 PARIS 18 FRANCE HOP BEAUJON,SERV HEPATOL CLICHY FRANCE HOP BEAUJON,INSERM,U24 F-92118 CLICHY FRANCE UFR SCI PHARMACEUT PARIS FRANCE
Titolo Testata:
Journal of hepatology
fascicolo: 2, volume: 26, anno: 1997,
pagine: 265 - 271
SICI:
0168-8278(1997)26:2<265:SSOSGF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ALPHA-1-ACID GLYCOPROTEIN; LENS-CULINARIS AGGLUTININ; HEPATOCELLULAR-CARCINOMA; ALPHA-FETOPROTEIN; LIVER-DISEASE; CIRRHOTIC-PATIENTS; SUGAR CHAINS; ALPHA-1-ANTITRYPSIN; CONCANAVALIN; BINDING;
Keywords:
ALPHA-1-ANTITRYPSIN; ALPHA-FETOPROTEIN; ALPHA-1-6 FUCOSYLATION; TRANSFERRIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
N. Seta et al., "SEQUENTIAL STUDY OF SERUM GLYCOPROTEIN FUCOSYLATION IN ACUTE HEPATITIS", Journal of hepatology, 26(2), 1997, pp. 265-271

Abstract

Background: alpha-Fetoprotein is a useful diagnostic marker in hepatocellular carcinoma, during which its serum level increases and its glycan structure is hyperfucosylated. Normally-expressed glycoproteins (alpha 1-antitrypsin and transferrin) are also hyperfucosylated in hepatocellular carcinoma. alpha-fetoprotein serum levels are also increasedin conditions associated with hepatic regeneration, such as acute hepatitis. We conducted a longitudinal study of the alpha 1-6 fucosylation pattern of serum alpha-fetoprotein in ten patients with acute hepatitis and compared it to that of transferrin and alpha 1-antitrypsin. Methods: Protein levels were measured by using immunochemical assays. Crossed affinoimmunoelectrophoresis in the presence of Lens culinaris agglutinin was performed for each protein, and the fucosylation index, corresponding to the agglutinin reactive fraction, was determined. The results were compared to those in 25 healthy donors and five newborns. Results: alpha-Fetoprotein was hyperfucosylated and remained stable throughout the course of the disease. In contrast, serum transferrin and alpha 1-antitrypsin gradually became hyperfucosylated during the course of acute hepatitis. The transferrin and alpha 1-antitrypsin fucosylation indexes correlated with each other, but not with the alpha-fetoprotein fucosylation index. No correlation was found between alpha-fetoprotein, alpha 1-antitrypsin and transferrin fucosylation indexes andthe corresponding glycoprotein serum levels. Conclusions: Hyperfucosylation of alpha-fetoprotein is not specific to hepatocellular carcinoma. Increased alpha 1-6 fucosylation should not be considered solely asa tumour marker, but might also reflect cell proliferation. The studyof alpha 1-6 hyperfucosylation process of normally-expressed glycoproteins awaits further investigation, to test its usefulness as a new marker of liver regeneration during the follow-up of acute hepatitis.

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Documento generato il 30/11/20 alle ore 06:54:45