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Titolo: A GENERALIZED PENCIL BEAM ALGORITHM FOR OPTIMIZATION OF RADIATIONTHERAPY
Autore: GUSTAFSSON A; LIND BK; BRAHME A;
 Indirizzi:
 STOCKHOLM UNIV,KAROLINSKA INST,DEPT MED RADIAT PHYS,POB 260 S17176 STOCKHOLM SWEDEN
 Titolo Testata:
 Medical physics
fascicolo: 3,
volume: 21,
anno: 1994,
pagine: 343  357
 SICI:
 00942405(1994)21:3<343:AGPBAF>2.0.ZU;23
 Fonte:
 ISI
 Lingua:
 ENG
 Soggetto:
 COMPUTEDTOMOGRAPHY; PHOTON BEAMS; RADIOTHERAPY; ENERGY; BRACHYTHERAPY; COLLIMATION; TUMOR;
 Keywords:
 RADIATION THERAPY OPTIMIZATION; ENERGY FLUENCE OPTIMIZATION; TREATMENT OBJECTIVES; COMPLICATIONFREE CONTROL;
 Tipo documento:
 Article
 Natura:
 Periodico
 Settore Disciplinare:
 Science Citation Index Expanded
 Citazioni:
 45
 Recensione:
 Indirizzi per estratti:



 Citazione:
 A. Gustafsson et al., "A GENERALIZED PENCIL BEAM ALGORITHM FOR OPTIMIZATION OF RADIATIONTHERAPY", Medical physics, 21(3), 1994, pp. 343357
Abstract
An iterative pencil beam algorithm for optimization of multidimensional radiation therapy dose plans has been developed. The algorithm allows the use of both physical and radiobiological treatment objective functions and allows arbitrary sampling such as straight Cartesian gridswith linear or nonlinear sampling functions or random sampling. The algorithm can account for and optimally combine almost all the degrees of freedom at an advanced radiotherapy clinic, such as different beam modalities and spectra, beam directions, beam fluence distributions, and timedose fractionations. The algorithm allows for external chargedand neutral beams as well as intracavitary and interstitial sources to be optimally combined. A quantity termed the generalized fluence vector is introduced, combining fluences and energy fluences from external beams as well as the radiation source densities of intracavity and interstitial sources or external source distributions. The positivity constraint on the generalized fluence can therefore be applied directlyduring the optimization procedure. The convergence properties and therequired iteration time of the algorithm are discussed. Several examples with combinations of photon and electron beams of different energies and directions of incidence are presented. The optimization has been made with the treatment objective to maximize the probability of achieving tumor control without causing severe complications in healthy normal tissues.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:17:16