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Titolo:
SUBSTANCE-P SUPPRESSES THE ACTIVITY OF ALPHA(2)-ADRENOCEPTORS OF THE NUCLEUS-RETICULARIS GIGANTOCELLULARIS INVOLVED IN CARDIOVASCULAR REGULATION IN THE RAT
Autore:
LEN WB; TSOU MY; CHAN SHH; CHAN JYH;
Indirizzi:
VET GEN HOSP,DEPT MED RES TAIPEI 11217 TAIWAN VET GEN HOSP,DEPT MED RES TAIPEI 11217 TAIWAN VET GEN HOSP,DEPT ANESTHESIOL TAIPEI 11217 TAIWAN NATL YANG MING MED COLL,INST PHARMACOL TAIPEI 11221 TAIWAN
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 638, anno: 1994,
pagine: 227 - 234
SICI:
0006-8993(1994)638:1-2<227:SSTAOA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; MEDULLA-OBLONGATA; IMMUNOREACTIVE NEURONS; NOREPINEPHRINE RELEASE; VENTROLATERAL MEDULLA; BARORECEPTOR REFLEX; VASOMOTOR RESPONSES; TRACTUS SOLITARIUS; ANGIOTENSIN-III; VENTRAL MEDULLA;
Keywords:
SUBSTANCE P; ALPHA(2)-ADRENOCEPTOR; GUANABENZ; NEUROMODULATION; NUCLEUS RETICULARIS GIGANTOCELLULARIS; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
W.B. Len et al., "SUBSTANCE-P SUPPRESSES THE ACTIVITY OF ALPHA(2)-ADRENOCEPTORS OF THE NUCLEUS-RETICULARIS GIGANTOCELLULARIS INVOLVED IN CARDIOVASCULAR REGULATION IN THE RAT", Brain research, 638(1-2), 1994, pp. 227-234

Abstract

We evaluated possible interactions between substance P (SP) and the alpha(2)-adrenoceptors in the nucleus reticularis gigantocellularis (NRGC) of the medulla oblongata involved in cardiovascular regulation. Adult, male Sprague-Dawley rats anesthetized with pentobarbital sodium (40 mg/kg, i.p., with 10 mg/kg/h i.v. supplements) were used. The circulatory suppressant efficacy of a centrally acting alpha(2)-adrenoceptor agonist, guanabenz, was used as the experimental index. Bilateral microinjection of SP (300 or 600 pmol) into the NRGC, a medullary site that is critically involved in the cardiovascular depressive actions ofguanabenz, significantly diminished the hypotensive and bradycardiac efficacy of the aminoguanidine compound (100 mu g/kg, i.v.). This implied reduction in alpha(2)-adrenoceptor activity in the NRGC by SP was antagonized by its selective receptor antagonist, [D-Pro(2),D-Trp(7,9)]-SP (1200 pmol). Similarly, attenuation by SP of the cardiovascular suppressant effects of guanabenz was also reversed by immunocytochemically verified depletion of dopamine-beta-hydroxylase-immunoreactive nerve terminals in the NRGC, elicited by the selective noradrenergic neurotoxin, DSP4 (50 mu g) These data suggest that SP may exert an inhibitory action on the alpha(2)-adrenoceptors in the NRGC that are involvedin central cardiovascular regulation, possibly via a presynaptic modulation on noradrenergic neurotransmission.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 07:41:55