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Titolo:
GABAERGIC AND DOPAMINERGIC TRANSMISSION IN THE BRAIN OF ROMAN HIGH-AVOIDANCE AND ROMAN LOW-AVOIDANCE RATS
Autore:
GIORGI O; ORLANDI M; ESCORIHUELA RM; DRISCOLL P; LECCA D; CORDA MG;
Indirizzi:
UNIV CAGLIARI,DEPT TOXICOL,VIALE A DIAZ I-09126 CAGLIARI ITALY AUTONOMOUS UNIV BARCELONA,DEPT PHARMACOL & PSYCHIAT,MED PSYCHOL UNIT BARCELONA SPAIN INST ANIM SCI ZURICH SWITZERLAND
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 638, anno: 1994,
pagine: 133 - 138
SICI:
0006-8993(1994)638:1-2<133:GADTIT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; STRESS-INDUCED INCREASE; PREFRONTAL CORTEX; BENZODIAZEPINE RECEPTORS; CEREBRAL-CORTEX; GENETIC-DIFFERENCES; RECOGNITION SITES; BETA-CARBOLINES; BINDING-SITES; DOPAC LEVELS;
Keywords:
GABA(A) RECEPTOR; [S-35] TBPS BINDING; CL-36- UPTAKE; ROMAN HIGH- AND LOW-AVOIDANCE RATS; D-1 DOPAMINE RECEPTORS; STRESS; PSYCHOGENETIC SELECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
O. Giorgi et al., "GABAERGIC AND DOPAMINERGIC TRANSMISSION IN THE BRAIN OF ROMAN HIGH-AVOIDANCE AND ROMAN LOW-AVOIDANCE RATS", Brain research, 638(1-2), 1994, pp. 133-138

Abstract

The GABAergic and dopaminergic pathways in the central nervous system(CNS) play a pivotal role in the control of emotions and in the adaptive responses to stressful stimuli. The present study was aimed at characterizing a range of biochemical markers of GABA- and dopamine-mediated neurotransmission in the CNS of Roman high-avoidance (RHA/Verh) and Roman low-avoidance (RLA/ Verh) rats, two psychogenetically selectedlines that differ in their level of emotionality. The stimulatory effect of GABA on Cl-36(-) uptake was less pronounced in the cerebral cortex of RLA/Verh rats as compared to RHA/Verh rats, whereas no line-related changes were detected in [H-3]GABA and [H-3]flunitrazepam binding. On the other hand, the density of D-1 dopamine receptors labeled with [H-3]SCH 23390 was lower in the nucleus accumbens of RLA/Verh rats as compared to their RHA/Verh counterparts, whilst no line-dependent changes were observed in the binding parameters of D-1 dopamine receptors in the striatum, amygdala, and prefrontal cortex. These biochemical differences may contribute to the distinct emotionality and responsiveness to the effects of psychoactive drugs of RHA/Verh and RLA/ Verh rats.

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Documento generato il 29/03/20 alle ore 15:27:00