Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CHOLECYSTOKININ-OCTAPEPTIDE (CCK-8) INJECTED INTO A CEREBRAL VENTRICLE INDUCES A FEVER-LIKE THERMOREGULATORY RESPONSE MEDIATED BY TYPE-B CCK-RECEPTORS IN THE RAT
Autore:
SZELENYI Z; BARTHO L; SZEKELY M; ROMANOVSKY AA;
Indirizzi:
UNIV PECS,SCH MED,DEPT PATHOPHYSIOL,SZIGETI UT 12 H-7643 PECS HUNGARY UNIV PECS,SCH MED,DEPT PHARMACOL H-7643 PECS HUNGARY BYELARUSSIAN ACAD SCI,INST PHYSIOL MINSK BYELARUS
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 638, anno: 1994,
pagine: 69 - 77
SICI:
0006-8993(1994)638:1-2<69:C(IIAC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-BRAIN-BARRIER; FOOD-INTAKE; INDUCED HYPOTHERMIA; BODY-TEMPERATURE; PEPTIDES; ANTAGONIST; DOPAMINE; POTENT; NEUROPEPTIDES; HYPOTHALAMUS;
Keywords:
THERMOREGULATION; CCK8 AND CERULETIDE; PGE(1) FEVER; CENTRAL VS PERIPHERAL EFFECT; L364,718; L365,260;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
Z. Szelenyi et al., "CHOLECYSTOKININ-OCTAPEPTIDE (CCK-8) INJECTED INTO A CEREBRAL VENTRICLE INDUCES A FEVER-LIKE THERMOREGULATORY RESPONSE MEDIATED BY TYPE-B CCK-RECEPTORS IN THE RAT", Brain research, 638(1-2), 1994, pp. 69-77

Abstract

In conscious female Wistar rats with chronic lateral cerebroventricular cannula, the thermoregulatory effects of CCK-8, ceruletide and prostaglandin E(1)(PGE(1)) were studied. In addition, the possible involvement of type A or type B receptors of CCK-8 in thermoregulatory effects of PGE(1) and CCK-8 was also investigated. In the normothermic rat an intracerebroventricular (i.c.v.) injection of CCK-8 or ceruletide induced a thermogenic response with tail-skin vasoconstriction and a resulting rise in colonic temperature (T-c). There was a significant negative correlation between the starting level of T-c and the extent of rise in T-c following an i.c.v. administration of PGE(1), CCK-8 or ceruletide. Subcutaneously injected CCK-8 caused decreases in T-c in a cool ambient temperature as also described by others. The fever-like response to i.c.v. injected CCK-8 was attenuated by a CCK type B receptor blocker, but not by a CCK type A receptor blocker. Conversely, the hypothermic response to peripherally administered CCK-8 was attenuated bya type A receptor blocker, but not by a type B receptor blocker. Neither of these CCK-receptor blockers influenced the fever caused by an i.c.v. injection of PGE(1). It is concluded that in normothermic rats the thermogenic response observed after i.c.v. injection of CCK-8 and ceruletide is the most likely central thermoregulatory change mediated by CCK type B receptors, while the well-known hypothermic response observed after peripheral injection of these peptides might also be explained by their direct effect on variables influencing some of the thermoregulatory effector mechanisms at the periphery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 04:00:29