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Titolo:
LESIONS OF THE PEDUNCULOPONTINE TEGMENTAL NUCLEUS BLOCK DRUG-INDUCED REINFORCEMENT BUT NOT AMPHETAMINE-INDUCED LOCOMOTION
Autore:
OLMSTEAD MC; FRANKLIN KBJ;
Indirizzi:
MCGILL UNIV,DEPT PSYCHOL,1205 AVE DR PENFIELD MONTREAL H3A 1B1 PQ CANADA MCGILL UNIV,DEPT PSYCHOL MONTREAL H3A 1B1 PQ CANADA
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 638, anno: 1994,
pagine: 29 - 35
SICI:
0006-8993(1994)638:1-2<29:LOTPTN>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PONTINE RETICULAR-FORMATION; MEDIAL PREFRONTAL CORTEX; RAT SUBSTANTIA NIGRA; 6-HYDROXYDOPAMINE LESIONS; MESOPONTINE TEGMENTUM; MESOLIMBIC DOPAMINE; CHOLINERGIC SYSTEMS; PLACE PREFERENCE; 6-OHDA LESIONS; BASAL GANGLIA;
Keywords:
AMPHETAMINE; CONDITIONED PLACE PREFERENCE; LOCOMOTION; MESENCEPHALIC LOCOMOTOR REGION; MORPHINE; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; RAT; REINFORCEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
M.C. Olmstead e K.B.J. Franklin, "LESIONS OF THE PEDUNCULOPONTINE TEGMENTAL NUCLEUS BLOCK DRUG-INDUCED REINFORCEMENT BUT NOT AMPHETAMINE-INDUCED LOCOMOTION", Brain research, 638(1-2), 1994, pp. 29-35

Abstract

It has been proposed that the positive reinforcing and motor stimulating effects of drugs involve the activation of a common neural substrate. Reinforcing effects of food, drugs and brain stimulation are blocked by lesions of the pedunculopontine tegmental nucleus (PPTg), which is a component of the mesencephalic locomotor region. This has suggested that the PPTg may be involved in both positive reinforcement and forward locomotion. In four separate experiments, rats were prepared with NMDA (0.5 mu l of 0.1 M solution) or sham lesions of the PPTg. Animals in the first two experiments were tested for the development of a conditioned place preference (CPP) to morphine (2 mg/kg X 3 pairings) or amphetamine (1.5 mg/kg X 3 pairings). Ten days later, spontaneous motor activity (SMA) was assessed in these animals following a subcutaneous injection of saline or amphetamine (1.5 mg/kg). In two further experiments, drug-naive lesioned and control animals were tested for SMA only (saline or 1.5 mg/kg amphetamine in Experiment 3, and saline, 0.5mg/kg, or 3 mg/kg amphetamine in Experiment 4). Lesions of the PPTg blocked the development of a CPP to both morphine and amphetamine. In contrast, lesions had no effect on saline or amphetamine-stimulated SMA. The PPTg, therefore, appears to be involved in the reinforcing effects of amphetamine and morphine, but is not necessary for the expression of amphetamine-induced activity.

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Documento generato il 25/11/20 alle ore 07:03:28