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Titolo:
SINGLE INDICATOR OF RISK FOR SCHIZOPHRENIA - PROBABLE FACT OR LIKELY MYTH
Autore:
CLARIDGE G;
Indirizzi:
UNIV OXFORD,DEPT EXPTL PSYCHOL,S PARKS RD OXFORD OX1 3UD ENGLAND UNIV OXFORD MAGDALEN COLL OXFORD ENGLAND
Titolo Testata:
Schizophrenia bulletin
fascicolo: 1, volume: 20, anno: 1994,
pagine: 151 - 168
SICI:
0586-7614(1994)20:1<151:SIORFS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOTYPAL PERSONALITY-DISORDER; PRONE COLLEGE-STUDENTS; HEMISPHERE FUNCTION; PSYCHOSIS PRONENESS; PHYSICAL ANHEDONIA; NORMAL POPULATION; INTERHEMISPHERIC INTEGRATION; INDIVIDUAL-DIFFERENCES; PERCEPTUAL ABERRATION; COGNITIVE INHIBITION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
140
Recensione:
Indirizzi per estratti:
Citazione:
G. Claridge, "SINGLE INDICATOR OF RISK FOR SCHIZOPHRENIA - PROBABLE FACT OR LIKELY MYTH", Schizophrenia bulletin, 20(1), 1994, pp. 151-168

Abstract

The longitudinal followup strategy in high-risk research is being increasingly complemented by the use of psychosis-proneness scales to select subjects for study who might be vulnerable to schizophrenia and who show differences on laboratory measures that could act as endophenotypic markers for use in genetic investigations. Three types of experimental paradigm have been adopted, drawn from cognitive psychology, psychophysiology, and the neuropsychology of hemisphere function. Resultsadopting each of these approaches are examined, alongside recent factor-analytic evidence that psychosis-proneness scales currently in use tap up to four different components that map onto the clinical heterogeneity of schizophrenia (and possibly other forms of psychosis). No one of these components clearly emerges as, or points to, a single indicator of risk, though some aspect of neurocognitive functioning seems alikely candidate. Even so, it is argued, the clinical expression of vulnerability must be due to a convergence in an individual of several components of risk since individually (and notably so for ''susceptibility to positive symptoms'') they are very common in the healthy population. In evaluating the evidence, attention is drawn to two cruciallydifferent ways that investigators in schizophrenia research have construed the notion of continuity (1) as subclinical defect (or forme fruste of disease) having varying expression or (2) as biologically basedpersonality dimensions that simultaneously describe the dispositions to aberrations of function leading to degree of illness. It is noted that the model of continuity chosen can significantly shape the way theresults of risk research are interpreted and the theories of psychosis to which they give rise.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:12:12