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Titolo:
INCREASED NEUROPEPTIDE-Y CONCENTRATIONS IN SPECIFIC HYPOTHALAMIC REGIONS OF LACTATING RATS - POSSIBLE RELATIONSHIP TO HYPERPHAGIA AND ADAPTIVE-CHANGES IN ENERGY-BALANCE
Autore:
MALABU UH; KILPATRICK A; WARE M; VERNON RG; WILLIAMS G;
Indirizzi:
UNIV LIVERPOOL,DEPT MED,POB 147 LIVERPOOL L69 3BX ENGLAND HANNAH RES INST AYR KA6 5HL SCOTLAND
Titolo Testata:
Peptides
fascicolo: 1, volume: 15, anno: 1994,
pagine: 83 - 87
SICI:
0196-9781(1994)15:1<83:INCISH>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROWN ADIPOSE-TISSUE; STREPTOZOTOCIN-DIABETIC RATS; PARAVENTRICULAR NUCLEUS; FOOD-INTAKE; SYMPATHETIC ACTIVITY; ARCUATE NUCLEUS; MESSENGER-RNA; INSULIN; METABOLISM; EXPRESSION;
Keywords:
NEUROPEPTIDE Y; LACTATION; HYPERPHAGIA; HYPOTHALAMUS; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
U.H. Malabu et al., "INCREASED NEUROPEPTIDE-Y CONCENTRATIONS IN SPECIFIC HYPOTHALAMIC REGIONS OF LACTATING RATS - POSSIBLE RELATIONSHIP TO HYPERPHAGIA AND ADAPTIVE-CHANGES IN ENERGY-BALANCE", Peptides, 15(1), 1994, pp. 83-87

Abstract

Lactation is accompanied by hyperphagia and a reduction in brown adipose tissue (BAT) thermogenesis, which are unexplained. Neuropeptide Y (NPY) powerfully stimulates feeding and inhibits BAT thermogenesis when injected into the paraventricular nucleus and other specific regionsof the rat hypothalamus. We have tested the hypothesis that hypothalamic NPY activity is increased in lactating rats. Lactating rats consumed over four times as much food as nonlactating controls (n = 10; p < 0.001). Final plasma insulin concentrations in lactating rats were lower than in controls (6.8 +/- 0.8 vs. 11.7 +/- 2.1 pmol/l; p < 0.05) although plasma glucose and corticosterone concentrations were comparable (p > 0.05). Lactating rats showed significantly higher NPY levels than controls in specific hypothalamic regions, namely the arcuate nucleus-median eminence complex (a 41% rise; p < 0.001), paraventricular nucleus (35%; p < 0.001), ventromedial nucleus (66%; p = 0.003), and dorsomedial nucleus (78%; p < 0.001). Other hypothalamic regions showed no significant differences between groups. Increased NPY concentrationsin specific hypothalamic regions, particularly the arcuate nucleus where NPY is synthesized, suggest increased activity of the hypothalamicNPYergic system in lactation. Neuropeptide Y may mediate hyperphagia and reduced BAT thermogenesis in lactation. Hypoinsulinemia may be a stimulus to hypothalamic NPY in lactation, as has been postulated in other conditions of negative energy balance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 09:53:50