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Titolo:
2-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE DOES DEPENDENTLY REDUCE THE NUMBER OF TYROSINE HYDROXYLASE-IMMUNOREACTIVE CELLS IN THE SUBSTANTIA-NIGRA AND LOCUS-CERULEUS OF C57BL 6J MICE/
Autore:
FUKUDA T;
Indirizzi:
JIKEI UNIV SCH MED,INST NEUROSCI,DIV NEUROPATHOL,3-25-8 NISHI SHINBASHI,MINATO KU TOKYO 105 JAPAN
Titolo Testata:
Brain research
fascicolo: 2, volume: 639, anno: 1994,
pagine: 325 - 328
SICI:
0006-8993(1994)639:2<325:2DDRTN>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-METHYLISOQUINOLINIUM ION; MESENCEPHALIC DOPAMINERGIC-NEURONS; PARKINSONS-DISEASE; MONOAMINE-OXIDASE; N-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE; BRAIN; 1,2,3,4-TETRAHYDROISOQUINOLINE; TETRAHYDROISOQUINOLINE; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; PRECURSOR;
Keywords:
2-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE (2-MTIQ); C57BL/6J MOUSE; SUBSTANTIA-NIGRA; LOCUS CERULEUS; TYROSINE HYDROXYLASE; PARKINSONISM;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
T. Fukuda, "2-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE DOES DEPENDENTLY REDUCE THE NUMBER OF TYROSINE HYDROXYLASE-IMMUNOREACTIVE CELLS IN THE SUBSTANTIA-NIGRA AND LOCUS-CERULEUS OF C57BL 6J MICE/", Brain research, 639(2), 1994, pp. 325-328

Abstract

2-Methyl-1,2,3,4-tetrahydroisoquinoline (2-MTIQ) was administered chronically to C57BL/6J mice. Light and electron microscopic examinationsrevealed atrophic neurons restricted to the central portion of the substantia nigra pars compacta (SNc) and pars lateralis as well as a reduction in tyrosine hydroxylase immunoreactivity, which showed a significant inverse correlation with the dose administered in the SNc. 2-MTIQ may be a candidate endogenous or environmental factor that induces parkinsonism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:38:17