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Titolo:
REGULATION OF HUMAN INSULIN-RECEPTOR RNA SPLICING IN HEPG2 CELLS - EFFECTS OF GLUCOCORTICOID AND LOW GLUCOSE-CONCENTRATION
Autore:
NORGREN S; LI LS; LUTHMAN H;
Indirizzi:
KAROLINSKA HOSP,DEPT CLIN GENET,ROLF LUFT CTR DIABET RES S-10401 STOCKHOLM SWEDEN
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 1, volume: 199, anno: 1994,
pagine: 277 - 284
SICI:
0006-291X(1994)199:1<277:ROHIRS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIABETES-MELLITUS PATIENTS; MESSENGER-RNA; ALTERED EXPRESSION; GENE-EXPRESSION; VARIANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
S. Norgren et al., "REGULATION OF HUMAN INSULIN-RECEPTOR RNA SPLICING IN HEPG2 CELLS - EFFECTS OF GLUCOCORTICOID AND LOW GLUCOSE-CONCENTRATION", Biochemical and biophysical research communications, 199(1), 1994, pp. 277-284

Abstract

Human insulin receptor RNA is expressed in two alternatively spliced forms (Ex. 11- and Ex, 11+) encoding protein isoforms with discrete functional differences. In vivo, the splicing varies between tissues andchanges concomitantly with the control of glucose homeostasis. Recently, dexamethasone has been described to increase the relative expression of Ex. 11+ RNA molecules. In this study, we confirm that dexamethasone dose-dependently increases inclusion of exon 11, and demonstrate that low concentrations of glucose decrease inclusion. No effect was observed of either insulin or IGF1. These results suggest that hormonal as well as metabolic factors regulate the splicing of insulin receptorRNA in HepG2 cells. (C) 1994 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 04:31:15