Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MODULATION OF EPIDERMAL LANGERHANS CELL FREQUENCY BY TUMOR-NECROSIS-FACTOR-ALPHA
Autore:
CUMBERBATCH M; FIELDING I; KIMBER I;
Indirizzi:
ZENECA CENT TOXICOL LAB,ALDERLEY PK MACCLESFIELD SK10 4TJ CHESHIRE ENGLAND
Titolo Testata:
Immunology
fascicolo: 3, volume: 81, anno: 1994,
pagine: 395 - 401
SICI:
0019-2805(1994)81:3<395:MOELCF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRAINING LYMPH-NODES; COLONY-STIMULATING FACTOR; CONTACT-SENSITIZED MICE; BEARING DENDRITIC CELLS; FLUORESCEIN ISOTHIOCYANATE; HUMAN KERATINOCYTES; ICAM-1 EXPRESSION; MURINE EPIDERMIS; INDUCTION-PHASE; FACTOR RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
M. Cumberbatch et al., "MODULATION OF EPIDERMAL LANGERHANS CELL FREQUENCY BY TUMOR-NECROSIS-FACTOR-ALPHA", Immunology, 81(3), 1994, pp. 395-401

Abstract

During the induction phase of skin sensitization, dendritic cells (DC), many of which bear high levels of antigen, accumulate in lymph nodes draining the site of exposure. These DC derive from epidermal Langerhans' cells (LC) which are induced to migrate from the skin, via the afferent lymphatics, to lymph nodes. We demonstrated previously that intradermal exposure of mice to homologous; but not human, recombinant tumour necrosis factor-alpha (TNF-alpha) also causes an accumulation ofDC in draining nodes, the implication being that the local productionof this cytokine by epidermal cells provides one stimulus for LC migration. In the present study we have examined the influence of dermal TNF-alpha on the frequency of LC within the epidermis. Intradermal injection of mice with 25 ng or greater murine recombinant TNF-alpha caused a significant reduction in LC numbers within 30 min of exposure. Thesame treatment did not influence the frequency of Thy-1(+) epidermal DC. The density of LC was unaffected by the same amount of human TNF-alpha of comparable specific activity or by murine granulocyte-macrophage colony-stimulating factor (GM-CSF). These data provide additional evidence that TNF-alpha provides an important signal for the migration of LC from the epidermis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 06:07:08