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Titolo:
BCL-2 PROTEIN LOCALIZES TO THE CHROMOSOMES OF MITOTIC NUCLEI AND IS CORRELATED WITH THE CELL-CYCLE IN CULTURED EPITHELIAL-CELL LINES
Autore:
LU QL; HANBY AM; HAJIBAGHERI MAN; GSCHMEISSNER SE; LU PJ; TAYLORPAPADIMITRIOU J; KRAJEWSKI S; REED JC; WRIGHT NA;
Indirizzi:
IMPERIAL CANC RES FUND,HISTOPATHOL UNIT,POB 123,LINCOLNS INN FIELDS LONDON WC2A 3PX ENGLAND IMPERIAL CANC RES FUND,ELECTRON MICROSCOPY UNIT LONDON WC2A 3PX ENGLAND IMPERIAL CANC RES FUND,EPITHELIAL CELL BIOL LAB LONDON WC2A 3PX ENGLAND LA JOLLA CANC RES FDN,CANC RES CTR LA JOLLA CA 92037
Titolo Testata:
Journal of Cell Science
, volume: 107, anno: 1994,
parte:, 2
pagine: 363 - 371
SICI:
0021-9533(1994)107:<363:BPLTTC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
B-CELLS; C-MYC; FOLLICULAR LYMPHOMA; MEMBRANE PROTEIN; GROWTH; GENE; TRANSLOCATION; EXPRESSION; APOPTOSIS; DEATH;
Keywords:
BCL-2; CELL CYCLE; PROLIFERATION; EPITHELIAL CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
Q.L. Lu et al., "BCL-2 PROTEIN LOCALIZES TO THE CHROMOSOMES OF MITOTIC NUCLEI AND IS CORRELATED WITH THE CELL-CYCLE IN CULTURED EPITHELIAL-CELL LINES", Journal of Cell Science, 107, 1994, pp. 363-371

Abstract

bcl-2 gene expression confers a survival advantage by preventing cells from entering apoptosis. In contrast to the previously described cytoplasmic localization of Bcl-2 in epithelial eels in vivo, in this study we have demonstrated, in a series of human epithelial cell lines, that Bcl-2 also localizes to mitotic nuclei. Both immunocytochemical and immunoelectron microscopical examinations localize this protein to nuclei and in particular to chromosomes. Nuclear Bcl-2 expression in these cell lines is correlated with the cell cycle. There is relatively strong expression during mitosis, most intense during prophase and metaphase, declining in telophase and then the protein becomes undetectable soon after separation of the two daughter cells. The expression anddistribution of Bcl-2 is influenced by treatment with excessive thymidine, These results indicate that Bcl-2 may protect the cells from apoptosis occurring during mitosis and suggest a possible role for the protein in cell immortalization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 08:41:11