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Titolo:
EXPRESSION OF 11-BETA-OHSD ALONG THE NEPHRON OF MAMMALS AND HUMANS
Autore:
KENOUCH S; ALFAIDY N; BONVALET JP; FARMAN N;
Indirizzi:
UER XAVIER BICHAT,INSERM,U246,16 RUE HENRI HUCHARD F-75018 PARIS FRANCE
Titolo Testata:
Steroids
fascicolo: 2, volume: 59, anno: 1994,
pagine: 100 - 104
SICI:
0039-128X(1994)59:2<100:EO1ATN>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
11-BETA-HYDROXYSTEROID DEHYDROGENASE; RAT-KIDNEY; MINERALOCORTICOID RECEPTOR; ALDOSTERONE BINDING; ISOLATED TUBULES; RABBIT NEPHRON; LOCALIZATION; 11-BETA-DEHYDROGENASE; PROTECTOR; CELLS;
Keywords:
RENAL TUBULE; MINERALOCORTICOID RECEPTORS; ALDOSTERONE; GLUCOCORTICOID; REDUCTASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
S. Kenouch et al., "EXPRESSION OF 11-BETA-OHSD ALONG THE NEPHRON OF MAMMALS AND HUMANS", Steroids, 59(2), 1994, pp. 100-104

Abstract

The enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) plays a major role in the protection of the mineralocorticoid receptor (MR). This cellular mechanism of aldosterone selectivity relies on the coexpression of MR and 11 beta-OHSD in the same cells. Localization of renal 11 beta-OHSD along the nephron is reviewed; comparison of data contained in different species is made; and original data is presented to show that the catalytic activity of the enzyme in tubules from human kidney, is the highest in the mineralocorticoid-sensitive distal nephron.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:22:40