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Titolo:
VENTILATION STRATEGIES AFFECT SURFACTANT AGGREGATE CONVERSION IN ACUTE LUNG INJURY
Autore:
ITO Y; VELDHUIZEN RAW; YAO LJ; MCCAIG LA; BARTLETT AJ; LEWIS JF;
Indirizzi:
UNIV WESTERN ONTARIO,ST JOSEPHS HLTH CTR,LAWSON RES INST,DEPT MED,268GROSVENOR ST LONDON ON N6A 4V2 CANADA UNIV WESTERN ONTARIO,ST JOSEPHS HLTH CTR,LAWSON RES INST,DEPT MED LONDON ON N6A 4V2 CANADA UNIV WESTERN ONTARIO,ST JOSEPHS HLTH CTR,LAWSON RES INST,DEPT PHYSIOLLONDON ON N6A 4V2 CANADA
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 2, volume: 155, anno: 1997,
pagine: 493 - 499
SICI:
1073-449X(1997)155:2<493:VSASAC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; POSITIVE-PRESSURE VENTILATION; EXTRACORPOREAL CO2 REMOVAL; END-EXPIRATORY PRESSURE; HIGH TIDAL VOLUME; MECHANICAL VENTILATION; PULMONARY-EDEMA; ALVEOLAR SURFACTANT; AIRWAY PRESSURE; SP-B;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
Y. Ito et al., "VENTILATION STRATEGIES AFFECT SURFACTANT AGGREGATE CONVERSION IN ACUTE LUNG INJURY", American journal of respiratory and critical care medicine, 155(2), 1997, pp. 493-499

Abstract

This study evaluated the effects of varying tidal volumes (VT) and positive end-expiratory pressure (PEEP) levels on surfactant aggregate conversion and lung function in an animal model of lung injury induced by N-nitroso-N-methylurethane. Lung-injured adult rabbits were initially ventilated using a VT Of 10 ml/kg (VT10), a respiratory rate of 30 breaths/min (RR30), and a PEEP of 3.5 cm H2O. A trace dose of radiolabeled rabbit large surfactant aggregates was instilled after the onset of ventilation, and animals were then ventilated at different ventilator settings for 1 h. Ventilation strategies involving a lower VT (VT5,RR60) resulted in significantly superior oxygenation and lower surfactant aggregate conversion rates than strategies involving a higher VT ([VT10, RR30], [VT15, RR20], p < 0.05). Increasing the PEEP level to 8.0 cm H2O improved oxgenation, but it was sustained only with a low VT(VT5, RR60), and deteriorated with a high VT (VT10, RR30). Varying VTbut not PEEP levels resulted in significant changes in surfactant aggregate conversion. We conclude that increased surfactant aggregate conversion resulting from suboptimal ventilation of injured lungs may play an important role in the pathophysiology of ventilation-induced lungdysfunction in acute lung injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:13:33