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Titolo:
FUNCTIONAL DETERIORATION AND SELENIUM-VITAMIN-E TREATMENT IN MYOTONIC-DYSTROPHY - A PLACEBO-CONTROLLED STUDY
Autore:
ORNDAHL G; GRIMBY G; GRIMBY A; JOHANSSON G; WILHELMSEN L;
Indirizzi:
SAHLGRENS UNIV HOSP,DEPT REHABIL MED S-41345 GOTHENBURG SWEDEN SAHLGRENS UNIV HOSP,DEPT REHABIL MED S-41345 GOTHENBURG SWEDEN UNIV GOTEBORG,OSTRA HOSP,DEPT MED GOTHENBURG SWEDEN
Titolo Testata:
Journal of internal medicine
fascicolo: 3, volume: 235, anno: 1994,
pagine: 205 - 210
SICI:
0954-6820(1994)235:3<205:FDASTI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCULAR-DYSTROPHY;
Keywords:
DISABILITY; FUNCTIONAL DETERIORATION; MUSCLE STRENGTH; MYOTONIC DYSTROPHY; SPATIAL ABILITY; WALKING SPEED;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
G. Orndahl et al., "FUNCTIONAL DETERIORATION AND SELENIUM-VITAMIN-E TREATMENT IN MYOTONIC-DYSTROPHY - A PLACEBO-CONTROLLED STUDY", Journal of internal medicine, 235(3), 1994, pp. 205-210

Abstract

Objectives. The aim of the investigations was to study the effect of a combined selenium and vitamin E treatment in patients with myotonic dystrophy. Design. A double-blind placebo-controlled trial. Subjects, Twenty-seven patients with myotonic dystrophy divided into an experimental (n = 13) and a control (n = 14) group. Interventions. The experimental group was given increasing doses for 4 months up to a maximum of1.6 mg selenium and 800 mg vitamin E daily and the control group a corresponding number of placebo tablets. The total treatment period was 2 years. Main outcome measures. Muscle strength (knee extension, knee flexion, hand-grip), maximal walking speed for 30 m, function in dailyactivities (disability), well-being and cognitive functioning. Results. Before treatment, muscle strength showed moderately or markedly reduced values as did maximal walking speed. Disability was most markedlydemonstrated in instrumental ADL-activities. Spatial ability was reduced in the majority of patients. During the 2-year follow-up period, the hand-grip strength arid maximal walking speed decreased in both groups (P < 0.01). The reduction was not significantly different according to an 'intention-to-treat-analysis'. However, there was a significantly larger decline (P<0.01) in the left-hand grip strength in the control group when all the patients with complete treatment compliance were included. Conclusions. A useful set of measurements has been developed for following functional deterioration in myotonic dystrophy. No conclusive evidence of beneficial effects of selenium and vitamin E treatment has been produced.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:36:47