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Titolo:
ACUTE METHOTREXATE POISONING - SUCCESSFUL TREATMENT BY HEMODIALYSIS WITH ACTIVATED-CHARCOAL HEMOFILTRATION
Autore:
DALLAVALE F; COCHAT P; BOUFFET E; FRAPPAZ D; BIGOT P; VIAL M; GLASTRE C; FLORET D;
Indirizzi:
HOP EDOUARD HERRIOT,UNITE NEPHROL PEDIAT F-69437 LYON FRANCE
Titolo Testata:
Annales de pediatrie
fascicolo: 1, volume: 41, anno: 1994,
pagine: 60 - 63
SICI:
0066-2097(1994)41:1<60:AMP-ST>2.0.ZU;2-J
Fonte:
ISI
Lingua:
FRE
Keywords:
METHOTREXATE; ACUTE POISONING; ACUTE RENAL FAILURE; HEMODIALYSIS; CHARCOAL HEMOFILTRATION;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
F. Dallavale et al., "ACUTE METHOTREXATE POISONING - SUCCESSFUL TREATMENT BY HEMODIALYSIS WITH ACTIVATED-CHARCOAL HEMOFILTRATION", Annales de pediatrie, 41(1), 1994, pp. 60-63

Abstract

Methotrexate (MTX) is often used in high doses to treat malignant pediatric diseases. Intratubular precipitation of MTX and its metabolitesresults in renal failure responsible for potentially life-threateningsystemic accumulation of the drug. Prompt and effective dialysis is, therefore, the mainstay of treatment. Two patients (NL, 15 years ; EJ,10 years) were treated for inadvertent MTX overdosage by haemodialysis with charcoal haemofiltration (HD + CHP). Both patients had transient renal failure with anuria. Plasma MTX levels fell from 52 to 4.8 mumol/L after four HD + CHP sessions in patient NL; in patient EJ, three HD+CHP sessions with peritoneal dialysis for eight days reduced plasmaMTX levels from 612 to 0.5 mumol/L. Mean MTX extraction coefficients with HD+CHP were 65 % in NL and 71 % in EJ. Both patients had only mild systemic symptoms of drug toxicity and had virtually normal glomerular filtration rates after three and five years' follow-up for NL and EJ, respectively. These two cases demonstrate that haemodialysis with charcoal haemofiltration is effective in patients with acute methotrexate poisoning.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:52:54