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Titolo:
EFFECT OF A POLYVALENT BACTERIAL PREPARATION ON NATURAL-KILLER-CELL ACTIVITY IN CHILDREN WITH RECURRENT RESPIRATORY-INFECTIONS
Autore:
ROSSI ME; LEGA L; AZZARI C; RESTI M; MARRANCI S; DEMARCO A; CARBONELLA R; VIERUCCI A;
Indirizzi:
OSPED A MEYER,PEDIAT CLIN 3,VIA LUCA GIORDANO 13 I-50132 FLORENCE ITALY UNIV FLORENCE,DEPT PAEDIAT FLORENCE ITALY
Titolo Testata:
International journal of immunotherapy
fascicolo: 4, volume: 9, anno: 1993,
pagine: 225 - 233
SICI:
0255-9625(1993)9:4<225:EOAPBP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCLONAL ACTIVATION; HUMAN-LYMPHOCYTES; INFLUENZA-VIRUS; MODULATION; INHIBITION; ILLNESS; BIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Rossi et al., "EFFECT OF A POLYVALENT BACTERIAL PREPARATION ON NATURAL-KILLER-CELL ACTIVITY IN CHILDREN WITH RECURRENT RESPIRATORY-INFECTIONS", International journal of immunotherapy, 9(4), 1993, pp. 225-233

Abstract

Respiratory infections are the most frequent cause of illness in children, Recurrent respiratory infections (RRI) are found in 5 to 15% of children and represent an important problem both for children and their families and for paediatricians. In the present study natural killer(NK) cell activity has been studied in 30 children with RRI and the role of a polyvalent bacterial lysate in restoring depressed NK cell activity has been evaluated. The patients were randomized in two groups:the first group received sublingual administration of a polyvalent bacterial lysate for 1 month and the second group received, as a control, oral administration of a non-immunological tonic therapy for the same period. The results show that NK cell activity is significantly lower in children with RRI than in healthy children (p < 0.05). Moreover, a significant increase in NK activity was demonstrated in treated patients (p = 0.002) while no difference was observed in the control group. The values of NK activity between the two groups was not significantly different before the treatment while it was significantly higher intreated patients at the end of treatment (p = 0.008). No changes in haematological and blood chemistry values were demonstrated in the two groups. No side-effects were reported. The present study confirms thatbacterial immunomodulators are a safe tool which may be used to stimulate recovery from secondary immunodeficiencies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:32:40