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Titolo:
PATHOGENESIS OF POSTTRANSFUSION VIRAL-HEPATITIS IN CHILDREN WITH BETA-THALASSEMIA
Autore:
FEITELSON M; LEGA L; GUO JH; RESTI M; ROSSI ME; AZZARI C; BLUMBERG BS; VIERUCCI A;
Indirizzi:
THOMAS JEFFERSON UNIV,DEPT PATHOL & CELL BIOL,ROOM 219 ALUMNI HALL,1020 LOCUST ST PHILADELPHIA PA 19107 UNIV FLORENCE,DEPT PEDIAT I-50132 FLORENCE ITALY FOX CHASE CANC CTR PHILADELPHIA PA 19111
Titolo Testata:
Hepatology
fascicolo: 3, volume: 19, anno: 1994,
pagine: 558 - 568
SICI:
0270-9139(1994)19:3<558:POPVIC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
B VIRUS-INFECTION; POLYMERASE CHAIN-REACTION; ANTIGEN ANTIBODY MARKERS; X-GENE PRODUCT(S); TERM FOLLOW-UP; HEPADNAVIRUS INFECTIONS; NON-A; CIRCULATING ANTIBODIES; SEROLOGIC MARKERS; HBV INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
M. Feitelson et al., "PATHOGENESIS OF POSTTRANSFUSION VIRAL-HEPATITIS IN CHILDREN WITH BETA-THALASSEMIA", Hepatology, 19(3), 1994, pp. 558-568

Abstract

The pathogenesis of posttransfusion hepatitis was determined in 14 children with beta-thalassemia. All had blood samples obtained in 1980 or 1981, were vaccinated against hepatitis B virus in 1983 and had another serum sample collected in 1989. Seven children had detectable antibodies against hepatitis C virus before vaccination, and all were positive in 1989. With specific solid-phase enzyme immunoassays, all children had antibodies against hepatitis B virus, X and polymerase antigens in 1981, and six had one or both antibodies in 1989. Hepatitis B virus infection was confirmed by means of polymerase chain reaction, which demonstrated virus DNA in 13 of the 14 children. The amplification products spanning the X/precore region were smaller than expected, suggesting mutations in this region. Cloning and sequencing of these products revealed deletions spanning part or all of the X gene. The resultsshow that these children were infected with hepatitis B virus even without other markers in serum, that hepatitis B persists years after vaccination and that such infections are associated with the presence ofX deletion mutants. Coinfection with hepatitis B and C viruses, the former containing a new class of variants, is common in children with beta-thalassemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/10/20 alle ore 20:43:46