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Titolo:
IS THERE AN OPIATE RECEPTOR IN THE SNAIL MEGALOBULIMUS-SANCTIPAULI - ACTION OF MORPHINE AND NALOXONE
Autore:
ROMERO SMB; HOFFMANN A; MENESCALDEOLIVEIRA L;
Indirizzi:
UNIV SAO PAULO,FAC PHILOSOPHY SCI & LETTERS RIBEIRAO PRETO,DEPT BIOL BR-14040901 RIBEIRAO PRET SP BRAZIL USP,FAC MED RIBEIRAO PRETO BR-14049 RIBEIRAO PRET SP BRAZIL
Titolo Testata:
Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology
fascicolo: 1, volume: 107, anno: 1994,
pagine: 37 - 40
SICI:
1367-8280(1994)107:1<37:ITAORI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIATED ANALGESIC BEHAVIORS; CEPAEA-NEMORALIS; MAGNETIC-FIELDS; NERVOUS-SYSTEM; LAND SNAIL; ENKEPHALINS; IDENTIFICATION;
Keywords:
OPIATE RECEPTOR; MORPHINE; NALOXONE; SNAIL; NOCICEPTION; GASTROPOD; MOLLUSK; MEGALOBULIMUS SANCTIPAULI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
S.M.B. Romero et al., "IS THERE AN OPIATE RECEPTOR IN THE SNAIL MEGALOBULIMUS-SANCTIPAULI - ACTION OF MORPHINE AND NALOXONE", Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology, 107(1), 1994, pp. 37-40

Abstract

The effects of morphine sulfate (10, 15 and 20 mg/kg) or saline control (5 ml/kg) on the latency of the anterior body-lifting response to heat (avoidance response) were determined in four groups of snails Megalobulimus sanctipauli (n = 6) individually placed on a metal plate mounted on the surface of a water bath at 52 +/- 1 degrees C. The effectsof pre-treatment with naloxone hydrochloride (5 mg/kg) or saline (2.5ml/kg) control on the responses to morphine (15 mg/kg) were determined in two different groups of animals (n = 6). Administration of morphine resulted in an increase in the avoidance behavior latency with maximum effects occurring at 15 mg/kg, 10-15 min after injection. The effects of morphine disappeared within 90-120 min. Saline treatment had nodetectable effects on the latency of the response to an aversive stimulus. Naloxone significantly blocked (P < 0.05, Student paired t-test)the increase in avoidance behavior latency. The present results indicate that: 1. morphine has an antinociceptive effect on the response ofMegalobulimus sanctipauli to an aversive thermal stimulus; and 2. themorphine-induced ''analgesia'' may be caused by the stimulation of muopiate receptors.

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Documento generato il 01/10/20 alle ore 07:40:36