Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CLONAL PROLIFERATION OF LANGERHANS CELLS IN LANGERHANS CELL HISTIOCYTOSIS
Autore:
YU RC; CHU C; BULUWELA L; CHU AC;
Indirizzi:
ROYAL POSTGRAD MED SCH,DERMATOL UNIT LONDON W12 0NN ENGLAND ROYAL HOSP SICK CHILDREN,DEPT CHILD HLTH GLASGOW G3 8SJ SCOTLAND CHARING CROSS & WESTMINSTER MED SCH,DEPT BIOCHEM LONDON W6 ENGLAND
Titolo Testata:
Lancet
fascicolo: 8900, volume: 343, anno: 1994,
pagine: 767 - 768
SICI:
0140-6736(1994)343:8900<767:CPOLCI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
6
Recensione:
Indirizzi per estratti:
Citazione:
R.C. Yu et al., "CLONAL PROLIFERATION OF LANGERHANS CELLS IN LANGERHANS CELL HISTIOCYTOSIS", Lancet, 343(8900), 1994, pp. 767-768

Abstract

X-chromosome-inactivation assays can be used to assess clonality. We used such an assay at the human androgen-receptor gene locus in th reefemale patients with histologically proven Langerhans cell histiocytosis. All patients were heterozygous for this locus. Cells bearing the Langerhans cell phenotype were purified from involved tissue after fluorescence-activated cell sorting with monoclonal antibodies against the CD1a complex. After Hhal digestion of DNA, these CD1a positive cellsdemonstrated a non-random X-chromosome-inactivation pattern, whereas CD1a negative cells in the same tissue showed a random pattern. Our data suggest that Langerhans cell histiocytosis represents a clonal proliferation of cells bearing the Langerhans cell phenotype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:42:25